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Ch. 18 - Developmental Genetics
Sanders - Genetic Analysis: An Integrated Approach 3rd Edition
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
Chapter 18, Problem 25

Dipterans (two-winged insects) are thought to have evolved from a four-winged ancestor that had wings on both T2 and T3 thoracic segments, as in extant butterflies and dragonflies. Describe an evolutionary scenario for the evolution of dipterans from four-winged ancestors. What types of mutations could lead to a butterfly developing with only two wings?

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Understand the anatomical context: In insects, the thorax is divided into three segments—T1, T2, and T3. Wings typically develop on T2 and T3 in four-winged insects like butterflies and dragonflies, while dipterans have wings only on T2, with T3 bearing halteres (small balancing organs).
Consider the evolutionary changes: The transition from four wings to two wings likely involved changes in gene regulation that suppressed wing development on the T3 segment, transforming wings into halteres.
Identify key genetic players: Homeotic genes, especially those in the Hox gene complex such as Ultrabithorax (Ubx), control segment identity and appendage development. Mutations or changes in expression of these genes can alter the fate of T3 from wing to haltere.
Describe mutation types: Mutations could include regulatory mutations that change the expression pattern of Ubx, leading to repression of wing formation on T3, or coding mutations that alter the function of proteins involved in wing development pathways.
Summarize the evolutionary scenario: Natural selection could favor individuals with reduced wings on T3 if halteres provide better flight stability, leading over time to fixation of mutations that suppress T3 wing development and produce the dipteran two-winged body plan.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Evolutionary Modification of Thoracic Segments

Insects have three thoracic segments (T1, T2, T3), each potentially bearing wings. Dipterans evolved by losing or transforming the wings on the third segment (T3), resulting in only two functional wings on T2. Understanding how segment identity changes during evolution helps explain morphological differences between species.
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Homeotic (Hox) Gene Mutations

Homeotic genes control the identity of body segments during development. Mutations in these genes can cause one segment to develop features typical of another, such as wing loss or transformation. Changes in Hox gene expression can lead to the suppression or modification of wings on specific thoracic segments.
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Genetic and Developmental Mechanisms of Wing Formation

Wing development involves multiple genes regulating growth and patterning. Mutations affecting these genes can reduce or eliminate wing structures. For example, mutations in regulatory genes or signaling pathways can cause wings on T3 to be lost or transformed into halteres, as seen in dipterans.
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Related Practice
Textbook Question

The flowering jungle plant Lacandonia schismatica, discovered in southern Mexico, has a unique floral structure. Petal-like organs are in the outer whorls surrounding a number of carpels, and stamens are in the center of the flower. Closely related species are dioecious; female plants bear flowers that resemble those of Lacandonia, but without the central stamens. What type of mutation could have resulted in the evolution of Lacandonia flowers?

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Textbook Question

Homeotic genes are thought to regulate each other. What aspect of the phenotype of apetala2 agamous double mutants indicates that these two genes act antagonistically?

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Textbook Question

Homeotic genes are thought to regulate each other. Are similar interactions observed between Hox genes?

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Textbook Question

Basidiomycota is a monophyletic group of fungi that includes most of the common mushrooms. You are interested in the development of the body plan of mushrooms. How would you identify the genes required for patterning during mushroom development?

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Textbook Question

Zea mays (maize, or corn) was originally domesticated in central Mexico at least 7000 years ago from an endemic grass called teosinte. Teosinte is generally unbranched, has male and female flowers on the same branch, and has few kernels per 'cob,' each encased in a hard, leaf-like organ called a glume. In contrast, maize is highly branched, with a male inflorescence (tassel) on its central branch and female inflorescences (cobs) on axillary branches. In addition, maize cobs have many rows of kernels and soft glumes. George Beadle crossed cultivated maize and wild teosinte, which resulted in fully fertile F₁ plants. When the F₁ plants were self-fertilized, about 1 plant in every 1000 of the F₂ progeny resembled either a modern maize plant or a wild teosinte plant. What did Beadle conclude about whether the different architectures of maize and teosinte were caused by changes with a small effect in many genes or changes with a large effect in just a few genes?

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Textbook Question

In C. elegans there are two sexes: hermaphrodite and male. Sex is determined by the ratio of X chromosomes to haploid sets of autosomes (X/A). An X/A ratio of 1.0 produces a hermaphrodite (XX), and an X/A ratio of 0.5 results in a male (XO). In the 1970s, Jonathan Hodgkin and Sydney Brenner carried out genetic screens to identify mutations in three genes that result in either XX males (tra-1, tra-2) or XO hermaphrodites (her-1). Double-mutant strains were constructed to assess for epistatic interactions between the genes (see table). Propose a genetic model of how the her and tra genes control sex determination.

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