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Ch. 5 - Genetic Linkage and Mapping in Eukaryotes
Sanders - Genetic Analysis: An Integrated Approach 3rd Edition
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
Chapter 5, Problem 33a

DNA sequences for 10 individuals are
Table displaying nucleotide positions for 10 individuals, highlighting SNP variations across specific positions.
Identify the nucleotide positions of all SNPs (single nucleotide polymorphisms).

Verified step by step guidance
1
Step 1: Understand the concept of SNPs (Single Nucleotide Polymorphisms). SNPs are variations at a single nucleotide position in the DNA sequence among individuals. To identify SNPs, compare the nucleotide at each position across all individuals.
Step 2: Create a table or list to compare the nucleotide at each position (e.g., positions 1, 5, and 10) for all 10 individuals. This will help you systematically identify any variations.
Step 3: For each nucleotide position, check if there is more than one type of nucleotide present among the individuals. If there is variation, that position is an SNP.
Step 4: Record the positions where SNPs are found. For example, if at position 1, some individuals have 'G' while others have 'C', then position 1 is an SNP.
Step 5: Summarize the nucleotide positions that are identified as SNPs. These are the positions where genetic variation occurs among the individuals.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Single Nucleotide Polymorphisms (SNPs)

Single nucleotide polymorphisms (SNPs) are variations at a single nucleotide position in the DNA sequence among individuals. They can occur in coding regions, non-coding regions, or intergenic regions and are the most common type of genetic variation in humans. SNPs can influence traits, disease susceptibility, and response to drugs, making them crucial for genetic studies.
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Nucleotide Position

Nucleotide position refers to the specific location of a nucleotide within a DNA sequence. In the context of SNPs, identifying the nucleotide position is essential for determining where variations occur. This information is typically represented in a linear format, allowing researchers to compare sequences and pinpoint differences that may have biological significance.
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DNA Sequence Comparison

DNA sequence comparison involves analyzing the nucleotide sequences of different individuals to identify similarities and differences. This process is fundamental in genetics for detecting SNPs, as it allows researchers to observe variations at specific positions across multiple samples. By comparing sequences, scientists can infer genetic diversity and potential associations with phenotypic traits.
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Related Practice
Textbook Question

In experiments published in 1918 that sought to verify and expand the genetic linkage and recombination theory proposed by Morgan, Thomas Bregger studied potential genetic linkage in corn (Zea mays) for genes controlling kernel color (colored is dominant to colorless) and starch content (starchy is dominant to waxy). Bregger performed two crosses. In Cross 1, pure-breeding colored, starchy-kernel plants (C1 Wx/C1 Wx) were crossed to plants pure-breeding for colorless, waxy kernels (c1 wx/c1 wx). The F₁ of this cross were test-crossed to colorless, waxy plants. The test-cross progeny were as follows:

In Cross 2, plants pure-breeding for colored, waxy kernels (C1 wx/C1 wx) and colorless, starchy kernels (c1 Wx/c1 Wx) were mated, and their F₁ were test-crossed to colorless, waxy plants. The test-cross progeny were as follows:

Calculate the recombination frequency for each of the progeny groups.

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Textbook Question

In experiments published in 1918 that sought to verify and expand the genetic linkage and recombination theory proposed by Morgan, Thomas Bregger studied potential genetic linkage in corn (Zea mays) for genes controlling kernel color (colored is dominant to colorless) and starch content (starchy is dominant to waxy). Bregger performed two crosses. In Cross 1, pure-breeding colored, starchy-kernel plants (C1 Wx/C1 Wx) were crossed to plants pure-breeding for colorless, waxy kernels (c1 wx/c1 wx). The F₁ of this cross were test-crossed to colorless, waxy plants. The test-cross progeny were as follows:

In Cross 2, plants pure-breeding for colored, waxy kernels (C1 wx/C1 wx) and colorless, starchy kernels (c1 Wx/c1 Wx) were mated, and their F₁ were test-crossed to colorless, waxy plants. The test-cross progeny were as follows:

Taken together, are the results of these two experiments compatible with the hypothesis of genetic linkage? Explain why or why not.

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Textbook Question

In experiments published in 1918 that sought to verify and expand the genetic linkage and recombination theory proposed by Morgan, Thomas Bregger studied potential genetic linkage in corn (Zea mays) for genes controlling kernel color (colored is dominant to colorless) and starch content (starchy is dominant to waxy). Bregger performed two crosses. In Cross 1, pure-breeding colored, starchy-kernel plants (C1 Wx/C1 Wx) were crossed to plants pure-breeding for colorless, waxy kernels (c1 wx/c1 wx). The F₁ of this cross were test-crossed to colorless, waxy plants. The test-cross progeny were as follows:

In Cross 2, plants pure-breeding for colored, waxy kernels (C1 wx/C1 wx) and colorless, starchy kernels (c1 Wx/c1 Wx) were mated, and their F₁ were test-crossed to colorless, waxy plants. The test-cross progeny were as follows:

Merge the two sets of progeny data and determine the combined recombination frequency.

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Textbook Question

DNA sequences for 10 individuals are

How many different SNP haplotypes are represented in the data?

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Textbook Question

DNA sequences for 10 individuals are

What is the sequence of each haplotype?

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Textbook Question

DNA sequences for 10 individuals are

Identify the haplotype carried by each person.

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