Skip to main content
Pearson+ LogoPearson+ Logo
Ch. 5 - Genetic Linkage and Mapping in Eukaryotes
Sanders - Genetic Analysis: An Integrated Approach 3rd Edition
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
All textbooksSanders 3rd EditionCh. 5 - Genetic Linkage and Mapping in EukaryotesProblem 33c
Chapter 5, Problem 33c

DNA sequences for 10 individuals are

What is the sequence of each haplotype?

Verified step by step guidance
1
Identify the variable nucleotide positions in the DNA sequences provided. Compare the sequences of all 10 individuals to determine which nucleotide positions differ among them. For this problem, focus on positions 1, 5, and 10 as they show variation.
Group the sequences into distinct haplotypes based on the variable nucleotide positions. A haplotype is a combination of alleles (nucleotides) at multiple loci that are transmitted together. For example, if position 1 has 'G' or 'C', position 5 has 'A' or 'C', and position 10 has 'T' or 'G', then each unique combination of these nucleotides represents a haplotype.
List the unique haplotypes by examining the sequences of all individuals. For each individual, extract the nucleotides at the variable positions and group identical combinations together. For instance, if Person 1 has 'G' at position 1, 'A' at position 5, and 'T' at position 10, this forms one haplotype.
Count the number of individuals that belong to each haplotype group. This step helps in understanding the frequency of each haplotype in the population.
Summarize the haplotypes and their frequencies. Present the unique haplotypes as sequences of nucleotides at the variable positions and indicate how many individuals share each haplotype.

Verified video answer for a similar problem:

This video solution was recommended by our tutors as helpful for the problem above.
Video duration:
3m
Was this helpful?

Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Haplotypes

A haplotype is a group of genes within an organism that are inherited together from a single parent. It refers to a specific combination of alleles or a sequence of DNA variations that are located close to each other on a chromosome. Understanding haplotypes is crucial for analyzing genetic variation and inheritance patterns among individuals.

DNA Sequencing

DNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule. This technique allows researchers to identify variations in the genetic code, which can be critical for understanding genetic relationships and differences among individuals. In the context of the question, sequencing helps in identifying the specific haplotypes present in the individuals listed.
Recommended video:
Guided course
08:41
Sequencing Difficulties

Alleles

Alleles are different versions of a gene that can exist at a specific locus on a chromosome. Each individual inherits two alleles for each gene, one from each parent, which can be identical or different. The combination of alleles contributes to the genetic diversity observed in populations and is essential for determining the haplotypes of the individuals in the given sequences.
Recommended video:
Guided course
03:03
New Alleles and Migration
Related Practice
Textbook Question

In experiments published in 1918 that sought to verify and expand the genetic linkage and recombination theory proposed by Morgan, Thomas Bregger studied potential genetic linkage in corn (Zea mays) for genes controlling kernel color (colored is dominant to colorless) and starch content (starchy is dominant to waxy). Bregger performed two crosses. In Cross 1, pure-breeding colored, starchy-kernel plants (C1 Wx/C1 Wx) were crossed to plants pure-breeding for colorless, waxy kernels (c1 wx/c1 wx). The F₁ of this cross were test-crossed to colorless, waxy plants. The test-cross progeny were as follows:

In Cross 2, plants pure-breeding for colored, waxy kernels (C1 wx/C1 wx) and colorless, starchy kernels (c1 Wx/c1 Wx) were mated, and their F₁ were test-crossed to colorless, waxy plants. The test-cross progeny were as follows:

Merge the two sets of progeny data and determine the combined recombination frequency.

529
views
Textbook Question

DNA sequences for 10 individuals are

Identify the nucleotide positions of all SNPs (single nucleotide polymorphisms).

471
views
Textbook Question

DNA sequences for 10 individuals are

How many different SNP haplotypes are represented in the data?

464
views
Textbook Question

DNA sequences for 10 individuals are

Identify the haplotype carried by each person.

500
views
Textbook Question

The accompanying pedigree below shows a family in which an autosomal recessive disorder is present. Family members I-2 and II-2 are affected by the disorder and have the genotype dd. A pregnancy involving II-4 has just undergone genetic testing for a VNTR that is linked to the disease gene. The VNTR has a recombination frequency of r = 20 with the disease gene. The VNTR has two alleles, V1 and V2. The gel electrophoresis patterns for each family member are shown, including the VNTR genotype for II-4. Based on the information given, answer the following questions about the family.

Excluding II-4, what is the genotype of each family member for the disease gene?

1322
views
Textbook Question

The accompanying pedigree below shows a family in which an autosomal recessive disorder is present. Family members I-2 and II-2 are affected by the disorder and have the genotype dd. A pregnancy involving II-4 has just undergone genetic testing for a VNTR that is linked to the disease gene. The VNTR has a recombination frequency of r = 20 with the disease gene. The VNTR has two alleles, V1 and V2. The gel electrophoresis patterns for each family member are shown, including the VNTR genotype for II-4. Based on the information given, answer the following questions about the family.

What is the genotype of each family member, including II-4, for the VNTR?

624
views