Textbook Question
Explain why Avery, MacLeod, and McCarty's in vitro transformation experiment showed that DNA, but not RNA or protein, is the hereditary molecule.
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Ch. 7 - DNA Structure and Replication
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172
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Table of contents
- Ch. 1 - The Molecular Basis of Heredity, Variation, and Evolution64
- Ch. 2 - Transmission Genetics144
- Ch. 3 - Cell Division and Chromosome Heredity81
- Ch. 4 - Gene Interaction87
- Ch. 5 - Genetic Linkage and Mapping in Eukaryotes103
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages73
- Ch. 7 - DNA Structure and Replication71
- Ch. 8 - Molecular Biology of Transcription and RNA Processing79
- Ch. 9 - The Molecular Biology of Translation110
- Ch. 10 - Eukaryotic Chromosome Abnormalities and Molecular Organization100
- Ch. 11 - Gene Mutation, DNA Repair, and Homologous Recombination86
- Ch. 12 - Regulation of Gene Expression in Bacteria and Bacteriophage90
- Ch. 13 - Regulation of Gene Expression in Eukaryotes38
- Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics72
- Ch. 15 - Recombinant DNA Technology and Its Applications69
- Ch. 16 - Genomics: Genetics from a Whole-Genome Perspective49
- Ch. 17 - Organelle Inheritance and the Evolution of Organelle Genomes27
- Ch. 18 - Developmental Genetics43
- Ch. 19 - Genetic Analysis of Quantitative Traits66
- Ch. 20 - Population Genetics and Evolution at the Population, Species, and Molecular Levels105
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
Chapter 7, Problem 5a
One strand of a fragment of duplex DNA has the sequence 5'-ATCGACCTGATC-3'.
What is the sequence of the other strand in the duplex?
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Identify the sequence of the given DNA strand: 5'-ATCGACCTGATC-3'.
Recall the base-pairing rules in DNA: Adenine (A) pairs with Thymine (T), and Cytosine (C) pairs with Guanine (G).
Write the complementary sequence by pairing each base with its complement: A pairs with T, T pairs with A, C pairs with G, and G pairs with C.
Reverse the direction of the complementary strand to ensure it is written in the 5' to 3' direction, as DNA strands are antiparallel.
The final complementary sequence will be the reverse complement of the original strand, written in the 5' to 3' orientation.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Complementary Base Pairing
In DNA, the two strands are held together by complementary base pairing, where adenine (A) pairs with thymine (T) and cytosine (C) pairs with guanine (G). This means that for every A in one strand, there is a T in the opposite strand, and for every C, there is a G. Understanding this pairing is essential for determining the sequence of the complementary strand.
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Base Distortions
DNA Strand Orientation
DNA strands have directionality, indicated by the 5' and 3' ends. The 5' end has a phosphate group, while the 3' end has a hydroxyl group. When writing DNA sequences, the convention is to list them from the 5' to 3' direction, which is crucial for accurately determining the complementary strand's sequence.
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Antiparallel Structure of DNA
The two strands of DNA run in opposite directions, a feature known as antiparallel orientation. This means that if one strand runs from 5' to 3', the complementary strand runs from 3' to 5'. This structural characteristic is important for understanding how the strands interact and how replication and transcription processes occur.
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Related Practice
Textbook Question
Hershey and Chase selected the bacteriophage T2 for their experiment assessing the role of DNA in heredity because T2 contains protein and DNA, but not RNA. Explain why T2 was a good choice for this experiment.
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Textbook Question
Explain how the Hershey and Chase experiment identified DNA as the hereditary molecule.
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Textbook Question
One strand of a fragment of duplex DNA has the sequence 5'-ATCGACCTGATC-3'.
What is the name of the bond that joins one nucleotide to another in the DNA strand?
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Textbook Question
One strand of a fragment of duplex DNA has the sequence 5'-ATCGACCTGATC-3'.
Is the bond in part (b) a covalent or a noncovalent bond?
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Textbook Question
One strand of a fragment of duplex DNA has the sequence 5'-ATCGACCTGATC-3'.
Which chemical groups of nucleotides react to form the bond in part (b)?
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