BackThe Knoevenagel condensation is a special case of the aldol condensation in which an active methylene compound reacts with an aldehyde or ketone, in the presence of a secondary amine as a basic catalyst, to produce a new C=C. Show the starting materials that made each of these by a Knoevenagel condensation.
(e)
The Knoevenagel condensation is a special case of the aldol condensation in which an active methylene compound reacts with an aldehyde or ketone, in the presence of a secondary amine as a basic catalyst, to produce a new C=C. Show the starting materials that made each of these by a Knoevenagel condensation.
(f)
Propose mechanisms for the reactions shown in Problems 22-63 part (a).
Predict the products of these reaction sequences.
Show how you would use an aldol, Claisen, or another type of condensation to make each compound.
(c)
Propose mechanisms for the reactions shown in Problems 22-62 part (a).
Many of the condensations we have studied are reversible. The reverse reactions are often given the prefix retro-, the Latin word meaning “backward.” Propose mechanisms to account for the following reactions.
(a)
Many of the condensations we have studied are reversible. The reverse reactions are often given the prefix retro-, the Latin word meaning “backward.” Propose mechanisms to account for the following reactions.
(b)
Biochemists studying the structure of collagen (a fibrous protein in connective tissue) found cross-links containing α,β-unsaturated aldehydes between protein chains. Show the structures of the side chains that react to form these cross-links, and propose a mechanism for their formation in a weakly acidic solution.
Propose mechanisms for the following reactions.
(a)
Show how the following compounds can be synthesized. The only carbon-containing compounds available to you for each synthesis are shown.
b.