Tay–Sachs disease is an autosomal recessive neurological disorder that is fatal in infancy. Despite its invariably lethal effect, Tay–Sachs disease occurs at very high frequency in some Central and Eastern European (Ashkenazi) Jewish populations. In certain Ashkenazi populations, 1 in 750 infants has Tay–Sachs disease. Population biologists believe the high frequency is a consequence of genetic bottlenecks caused by pogroms (genocide) that have reduced the population multiple times in the past several hundred years. In the population described, what is the frequency of the recessive allele that produces Tay–Sachs disease?
Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
21. Population Genetics
Allelic Frequency Changes
Problem 23
Textbook Question
What genetic changes take place during speciation?
Verified step by step guidance1
Understand that speciation is the process by which populations evolve to become distinct species, often involving genetic divergence.
Identify that genetic changes during speciation typically include mutations, which introduce new alleles into the gene pool.
Recognize that genetic drift and natural selection act on these mutations, causing allele frequencies to change over time in isolated populations.
Consider that reproductive isolation mechanisms develop, which can be prezygotic (before fertilization) or postzygotic (after fertilization), reducing gene flow between populations.
Summarize that the accumulation of genetic differences, such as chromosomal rearrangements or gene flow barriers, leads to the formation of new species.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Speciation
Speciation is the evolutionary process by which populations evolve to become distinct species. It involves the accumulation of genetic differences that lead to reproductive isolation, preventing gene flow between populations and allowing independent evolutionary paths.
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Genetic Divergence
Genetic divergence refers to the accumulation of genetic differences between populations due to mutation, natural selection, and genetic drift. Over time, these differences can lead to distinct traits and reproductive barriers essential for speciation.
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Descriptive Genetics
Reproductive Isolation
Reproductive isolation occurs when genetic changes prevent interbreeding between populations. It can be prezygotic (before fertilization) or postzygotic (after fertilization), and is crucial for maintaining species boundaries during and after speciation.
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