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Ch. 26 - Population and Evolutionary Genetics
Klug - Concepts of Genetics  12th Edition
Klug12th EditionConcepts of Genetics ISBN: 9780135564776Not the one you use?Change textbook
Chapter 26, Problem 20

A farmer plants transgenic Bt corn that is genetically modified to produce its own insecticide. Of the corn borer larvae feeding on these Bt crop plants, only 10 percent survive unless they have at least one copy of the dominant resistance allele B that confers resistance to the Bt insecticide. When the farmer first plants Bt corn, the frequency of the B resistance allele in the corn borer population is 0.02. What will be the frequency of the resistance allele after one generation of corn borers have fed on Bt corn?

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1
Identify the initial allele frequencies: let the frequency of the resistance allele B be \(p = 0.02\), and the frequency of the susceptible allele b be \(q = 1 - p = 0.98\).
Calculate the genotype frequencies before selection using Hardy-Weinberg equilibrium: \(\text{freq}(BB) = p^2\), \(\text{freq}(Bb) = 2pq\), and \(\text{freq}(bb) = q^2\).
Apply the selection based on survival rates: individuals with at least one B allele (BB and Bb) survive at 100%, while bb individuals survive at 10%. Multiply each genotype frequency by its respective survival rate to get the post-selection genotype frequencies (unnormalized).
Normalize the post-selection genotype frequencies by dividing each by the total sum of the post-selection frequencies to ensure they sum to 1.
Calculate the new allele frequency \(p'\) of the resistance allele B after selection using the normalized genotype frequencies: \(p' = \text{freq}(BB) + \frac{1}{2} \times \text{freq}(Bb)\).

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Allele Frequency and Population Genetics

Allele frequency refers to how common a particular allele is in a population's gene pool. It is expressed as a proportion or percentage of all alleles for a specific gene. Changes in allele frequency over generations indicate evolutionary processes such as natural selection or genetic drift.
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Natural Selection and Fitness

Natural selection is the process where individuals with advantageous traits have higher survival and reproduction rates. Fitness measures an organism's reproductive success. In this case, larvae with the resistance allele B have higher fitness on Bt corn, leading to increased frequency of B in the next generation.
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Dominance and Genotype Fitness Effects

Dominance describes how alleles express in heterozygotes. Here, the resistance allele B is dominant, so individuals with one or two copies survive better. Understanding genotype-specific survival rates (e.g., BB, Bb, bb) is essential to calculate how allele frequencies change after selection.
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Related Practice
Textbook Question

A recent study examining the mutation rates of 5669 mammalian genes (17,208 sequences) indicates that, contrary to popular belief, mutation rates among lineages with vastly different generation lengths and physiological attributes are remarkably constant [Kumar, S., and Subramanian, S. (2002). Proc. Natl. Acad. Sci. USA 99:803–808]. The average rate is estimated at 12.2×10⁻⁹ per bp per year. What is the significance of this finding in terms of mammalian evolution?

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Textbook Question

What are considered significant factors in maintaining the surprisingly high levels of genetic variation in natural populations?

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Textbook Question

A botanist studying water lilies in an isolated pond observed three leaf shapes in the population: round, arrowhead, and scalloped. Marker analysis of DNA from 125 individuals showed the round-leaf plants to be homozygous for allele r1, while the plants with arrowhead leaves were homozygous for a different allele at the same locus, r2. Plants with scalloped leaves showed DNA profiles with both the r1 and r2 alleles. Frequency of the r1 allele was estimated at 0.81. If the botanist counted 20 plants with scalloped leaves in the pond, what is the inbreeding coefficient F for this population?

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Textbook Question

In an isolated population of 50 desert bighorn sheep, a mutant recessive allele c when homozygous causes curled coats in both males and females. The normal dominant allele C produces straight coats. A biologist studying these sheep counts four with curled coats. She also takes blood samples from the population for DNA analysis, which reveals that 17 of the sheep are heterozygous carriers of the c allele. What is the inbreeding coefficient F for this population?

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Textbook Question

To increase genetic diversity in the bighorn sheep population described in Problem 23, ten sheep are introduced from a population where the c allele is absent. Assuming that random mating occurs between the original and the introduced sheep, and that the c allele is selectively neutral, what will be the frequency of c in the next generation?

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Textbook Question

What genetic changes take place during speciation?

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