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Ch. 3 - Mendelian Genetics
Klug - Concepts of Genetics  12th Edition
Klug12th EditionConcepts of Genetics ISBN: 9780135564776Not the one you use?Change textbook
Chapter 3, Problem 20

The basis for rejecting any null hypothesis is arbitrary. The researcher can set more or less stringent standards by deciding to raise or lower the p value used to reject or not reject the hypothesis. In the case of the chi-square analysis of genetic crosses, would the use of a standard of p = 0.10 be more or less stringent about not rejecting the null hypothesis? Explain.

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1
Understand that the p-value in hypothesis testing represents the probability of obtaining results at least as extreme as those observed, assuming the null hypothesis is true.
Recognize that a lower p-value threshold (e.g., 0.05) means you require stronger evidence against the null hypothesis to reject it, making the test more stringent.
Conversely, a higher p-value threshold (e.g., 0.10) means you accept weaker evidence against the null hypothesis to reject it, making the test less stringent.
In the context of chi-square analysis of genetic crosses, using a p-value standard of 0.10 means you are more willing to reject the null hypothesis even if the evidence is not very strong.
Therefore, setting the p-value at 0.10 is less stringent about not rejecting the null hypothesis compared to a lower p-value standard like 0.05.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Null Hypothesis and Significance Level (p-value)

The null hypothesis is a default assumption that there is no effect or difference. The p-value represents the probability of observing the data if the null hypothesis is true. A significance level (alpha) is set to decide when to reject the null hypothesis, commonly 0.05, meaning results with p-values below this threshold lead to rejection.
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Stringency of Significance Levels

Stringency refers to how strict the criteria are for rejecting the null hypothesis. A lower p-value threshold (e.g., 0.01) is more stringent, requiring stronger evidence to reject the null. Conversely, a higher p-value threshold (e.g., 0.10) is less stringent, making it easier to reject the null hypothesis.
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Chi-square Test in Genetic Crosses

The chi-square test compares observed genetic data to expected ratios under the null hypothesis of no difference. It calculates a p-value to assess if deviations are due to chance. The chosen p-value threshold determines whether the genetic data significantly deviate from expected Mendelian ratios.
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Related Practice
Textbook Question

Thalassemia is an inherited anemic disorder in humans. Affected individuals exhibit either a minor anemia or a major anemia. Assuming that only a single gene pair and two alleles are involved in the inheritance of these conditions, is thalassemia a dominant or recessive disorder?

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Textbook Question

The following are F₂ results of two of Mendel's monohybrid crosses.

For each cross, state a null hypothesis to be tested using x² analysis. Calculate the x² value and determine the p value for both. Interpret the p-values. Can the deviation in each case be attributed to chance or not? Which of the two crosses shows a greater amount of deviation?

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Textbook Question

In assessing data that fell into two phenotypic classes, a geneticist observed values of 250:150. She decided to perform a χ\chi² analysis by using the following two different null hypotheses:

(a) the data fit a 3:1 ratio, and

(b) the data fit a 1:1 ratio.

Calculate the χ\chi ² values for each hypothesis. What can be concluded about each hypothesis?

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Textbook Question

Consider the following pedigree.

Predict the mode of inheritance of the trait of interest and the most probable genotype of each individual. Assume that the alleles A and a control the expression.

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Textbook Question

Draw all possible conclusions concerning the mode of inheritance of the trait portrayed in the following limited pedigree.

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Textbook Question

Draw all possible conclusions concerning the mode of inheritance of the trait portrayed in the following limited pedigree.

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