Textbook Question
Compare and contrast the genome, the proteome, and the transcriptome of an organism.
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Ch. 1 - The Molecular Basis of Heredity, Variation, and Evolution
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172
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Table of contents
- Ch. 1 - The Molecular Basis of Heredity, Variation, and Evolution64
- Ch. 2 - Transmission Genetics144
- Ch. 3 - Cell Division and Chromosome Heredity81
- Ch. 4 - Gene Interaction87
- Ch. 5 - Genetic Linkage and Mapping in Eukaryotes103
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages73
- Ch. 7 - DNA Structure and Replication71
- Ch. 8 - Molecular Biology of Transcription and RNA Processing79
- Ch. 9 - The Molecular Biology of Translation110
- Ch. 10 - Eukaryotic Chromosome Abnormalities and Molecular Organization100
- Ch. 11 - Gene Mutation, DNA Repair, and Homologous Recombination86
- Ch. 12 - Regulation of Gene Expression in Bacteria and Bacteriophage90
- Ch. 13 - Regulation of Gene Expression in Eukaryotes38
- Ch. 14 - Analysis of Gene Function via Forward Genetics and Reverse Genetics72
- Ch. 15 - Recombinant DNA Technology and Its Applications69
- Ch. 16 - Genomics: Genetics from a Whole-Genome Perspective49
- Ch. 17 - Organelle Inheritance and the Evolution of Organelle Genomes27
- Ch. 18 - Developmental Genetics43
- Ch. 19 - Genetic Analysis of Quantitative Traits66
- Ch. 20 - Population Genetics and Evolution at the Population, Species, and Molecular Levels105
Sanders3rd EditionGenetic Analysis: An Integrated ApproachISBN: 9780135564172Not the one you use?Change textbook
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Sanders 3rd EditionCh. 1 - The Molecular Basis of Heredity, Variation, and EvolutionProblem 14a
Sanders 3rd EditionCh. 1 - The Molecular Basis of Heredity, Variation, and EvolutionProblem 14aChapter 1, Problem 14a
Briefly describe the contribution each of the following people made to the development of genetics or genetic analysis.
Archibald Garrod
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Archibald Garrod was a British physician who made significant contributions to the field of genetics by studying inherited metabolic disorders.
He proposed the concept of 'inborn errors of metabolism,' suggesting that certain diseases are caused by defects in specific biochemical pathways due to genetic mutations.
Garrod's work on alkaptonuria, a condition where the body cannot properly break down homogentisic acid, demonstrated that this disorder followed Mendelian inheritance patterns.
He was one of the first to link genes to enzymes, laying the groundwork for the 'one gene-one enzyme' hypothesis later developed by Beadle and Tatum.
Garrod's research emphasized the importance of studying rare genetic disorders to understand broader principles of human genetics and biochemistry.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Inborn Errors of Metabolism
Archibald Garrod was a pioneer in the study of inborn errors of metabolism, which are genetic disorders caused by the absence or malfunction of specific enzymes. He proposed that these conditions were hereditary and linked to specific genes, laying the groundwork for understanding how genetic mutations can lead to metabolic diseases.
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Phenylketonuria (PKU)
Garrod's work on phenylketonuria (PKU) was significant in demonstrating how a single genetic defect could lead to a specific metabolic disorder. He showed that individuals with PKU could not properly metabolize phenylalanine, leading to severe health issues, thus highlighting the relationship between genes and metabolic pathways.
Genetic Analysis and Mendelian Inheritance
Garrod's contributions also emphasized the importance of Mendelian inheritance in understanding genetic disorders. He was one of the first to apply Mendel's principles to human diseases, suggesting that certain traits and conditions could be inherited in predictable patterns, which was crucial for the development of genetic analysis.
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Related Practice
Textbook Question
With respect to transcription describe the relationship and sequence correspondence of the RNA transcript and the DNA template strand. Describe the relationship and sequence correspondence of the mRNA transcript to the DNA coding strand.
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Textbook Question
Plant agriculture and animal domestication developed independently several times and in different locations in human history. Do a brief Internet search and then list the approximate locations, time periods, and crops developed in three of these agricultural events. What role do you think ideas about heredity may have played in these events?
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Textbook Question
Briefly describe the contribution each of the following people made to the development of genetics or genetic analysis.
Rosalind Franklin:
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Textbook Question
Briefly describe the contribution each of the following people made to the development of genetics or genetic analysis.
Robert Hooke
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Textbook Question
Briefly describe the contribution each of the following people made to the development of genetics or genetic analysis.
William Bateson:
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