Which observation suggested to Sutherland the involvement of a second messenger in epinephrine’s effect on liver cells?
a. Enzymatic activity was proportional to the amount of calcium added to a cell-free extract.
b. Receptor studies indicated that epinephrine was a ligand.
c. Glycogen breakdown was observed only when epinephrine was administered to intact cells.
d. Glycogen breakdown was observed only when epinephrine and glycogen phosphorylase were mixed.
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