Textbook Question
From the following table, draw up a list of histone H3 modifications associated with gene activation. Then draw up a list of H3 modifications associated with repression.
Are there any overlaps on the lists?
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Ch. 19 - Epigenetics
Klug12th EditionConcepts of Genetics ISBN: 9780135564776
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Table of contents
- Ch. 1 - Introduction to Genetics17
- Ch. 2 - Mitosis and Meiosis36
- Ch. 3 - Mendelian Genetics51
- Ch. 4 - Extensions of Mendelian Genetics74
- Ch. 5 - Chromosome Mapping in Eukaryotes51
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages46
- Ch. 7 - Sex Determination and Sex Chromosomes33
- Ch. 8 - Chromosome Mutations: Variation in Number and Arrangement40
- Ch. 9 - Extranuclear Inheritance31
- Ch. 10 - DNA Structure and Analysis43
- Ch. 11 - DNA Replication and Recombination44
- Ch. 12 - DNA Organization in Chromosomes30
- Ch. 13 - The Genetic Code and Transcription54
- Ch. 14 - Translation and Proteins47
- Ch. 15 - Gene Mutation, DNA Repair, and Transposition41
- Ch. 16 - Regulation of Gene Expression in Bacteria29
- Ch. 17 - Transcriptional Regulation in Eukaryotes41
- Ch. 18 - Post-transcriptional Regulation in Eukaryotes33
- Ch. 19 - Epigenetics33
- Ch. 20 - Recombinant DNA Technology44
- Ch. 21 - Genomic Analysis36
- Ch. 22 - Applications of Genetic Engineering and Biotechnology36
- Ch. 23 - Developmental Genetics37
- Ch. 24 - Cancer Genetics34
- Ch. 25 - Quantitative Genetics and Multifactorial Traits54
- Ch. 26 - Population and Evolutionary Genetics45
Chapter 19, Problem 23a
Amino acids are classified as positively charged, negatively charged, or electrically neutral.
Which category includes lysine?
Verified step by step guidance1
Understand the classification of amino acids: Amino acids are categorized based on the properties of their side chains (R groups). These categories include positively charged, negatively charged, and electrically neutral amino acids.
Recall the structure of lysine: Lysine is an amino acid with a side chain that contains an amino group (-NH2) at the end of a long aliphatic chain.
Determine the charge of lysine's side chain: The amino group in lysine's side chain can accept a proton (H⁺) under physiological pH, making it positively charged.
Compare lysine's properties to the amino acid categories: Positively charged amino acids have side chains that are basic and can carry a positive charge. Lysine fits this description.
Conclude the classification: Based on its positively charged side chain, lysine is classified as a positively charged amino acid.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Amino Acid Classification
Amino acids are organic compounds that serve as the building blocks of proteins. They are classified based on the properties of their side chains (R groups) into three categories: positively charged (basic), negatively charged (acidic), and electrically neutral (nonpolar or polar). This classification is crucial for understanding protein structure and function.
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Positively Charged Amino Acids
Positively charged amino acids, also known as basic amino acids, have side chains that contain amine groups, which can accept protons (H+ ions) at physiological pH. This results in a net positive charge. Common examples include lysine, arginine, and histidine, which play important roles in protein interactions and stability.
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07:
Positional Cloning
Lysine
Lysine is an essential amino acid classified as positively charged due to its side chain containing an amino group that can be protonated. It is crucial for protein synthesis, hormone production, and calcium absorption. Lysine's positive charge contributes to its interactions with negatively charged molecules, influencing protein structure and function.
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07:55Histone Protein Modifications
Related Practice
Textbook Question
From the following table, draw up a list of histone H3 modifications associated with gene activation. Then draw up a list of H3 modifications associated with repression.
Are these overlaps explained by different modifications?
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Textbook Question
From the following table, draw up a list of histone H3 modifications associated with gene activation. Then draw up a list of H3 modifications associated with repression.
If not, how can you reconcile these differences?
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Textbook Question
Amino acids are classified as positively charged, negatively charged, or electrically neutral.
How does this property of lysine allow it to interact with DNA?
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Textbook Question
Amino acids are classified as positively charged, negatively charged, or electrically neutral.
How does acetylation of lysine affect its interaction with DNA, and how is this related to the activation of gene expression?
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Textbook Question
Methylation of H3K9 by itself silences genes, but if H3K4 and H4K20 are also methylated, the combination of modifications stimulates transcription. What conclusions can you draw about this?
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