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Ch. 2 - Mitosis and Meiosis
Klug - Concepts of Genetics  12th Edition
Klug12th EditionConcepts of Genetics ISBN: 9780135564776Not the one you use?Change textbook
Chapter 2, Problem 15

A diploid cell contains three pairs of homologous chromosomes designated C1 and C2, M1 and M2, and S1 and S2. No crossing over occurs. What combinations of chromosomes are possible in?
(a) daughter cells following mitosis
(b) cells undergoing the first meiotic metaphase
(c) haploid cells following both divisions of meiosis

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1
Step 1: Understand the chromosome setup. The diploid cell has three pairs of homologous chromosomes: C1 and C2, M1 and M2, S1 and S2. Since no crossing over occurs, each chromosome remains intact and does not exchange segments with its homologous partner.
Step 2: For part (a), mitosis produces two daughter cells that are genetically identical to the parent cell. Each daughter cell receives one copy of each chromosome from each homologous pair. Therefore, the possible chromosome combinations in each daughter cell are exactly the same as the original diploid cell: C1 and C2, M1 and M2, S1 and S2.
Step 3: For part (b), during the first meiotic metaphase, homologous chromosomes pair up and align at the metaphase plate. The possible combinations here involve the arrangement of homologous pairs (C1 with C2, M1 with M2, S1 with S2) side by side. Since no crossing over occurs, the chromosomes remain intact, but their orientation can vary, which affects the combinations in the resulting cells.
Step 4: For part (c), after both meiotic divisions, haploid cells are formed. Each haploid cell contains one chromosome from each homologous pair. Because no crossing over occurs, the chromosomes are inherited as whole units. The possible combinations are all the different ways to inherit one chromosome from each pair (either C1 or C2, M1 or M2, S1 or S2).
Step 5: To summarize the combinations mathematically, use the formula for independent assortment: the number of possible combinations is \$2^n\(, where \)n\( is the number of chromosome pairs. Here, \)n=3\(, so the number of possible combinations in haploid cells after meiosis is \)2^3$. This reflects the different ways chromosomes can assort into gametes.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Mitosis and Chromosome Segregation

Mitosis is a type of cell division that results in two genetically identical daughter cells, each with the same number of chromosomes as the original diploid cell. Homologous chromosomes do not pair or segregate separately; instead, sister chromatids separate, ensuring each daughter cell receives one copy of each chromosome.
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Mitosis Steps

Meiosis I and Homologous Chromosome Pairing

During the first meiotic division, homologous chromosomes pair up and align at the metaphase plate. This pairing allows for the segregation of homologous chromosomes into two daughter cells, reducing the chromosome number by half. Since no crossing over occurs, chromosomes segregate as intact units.
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Haploid Cells after Meiosis II

Meiosis II resembles mitosis, where sister chromatids separate into individual chromosomes. After both meiotic divisions, the resulting haploid cells contain one chromosome from each homologous pair, representing all possible combinations of the original chromosomes without recombination.
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