Refer to the genetic coding dictionary to respond to the following:
A base-substitution mutation that altered the sequence shown in part (a) eliminated the synthesis of all but one polypeptide. The altered sequence is shown here:
5'-AUGCAUACCUAUGUGACCCUUGGA-3'
Determine why.

Question

Refer to the genetic coding dictionary to respond to the following:

A base-substitution mutation that altered the sequence shown in part (a) eliminated the synthesis of all but one polypeptide. The altered sequence is shown here:

5'-AUGCAUACCUAUGUGACCCUUGGA-3'

Determine why.

Accepted Answer

Hello everyone and welcome to today's video in an RNA sequence to be translated which we have here. A mutation occur where the mutated sequence led to the termination of protein synthesis after the formation of tyrosine. The mutated sequence we have here. This is the reason for the mutated sequence. And we're given two main choices. We can either do transition or trans version mutations. So if we look at the two sequences we can see that the mutation occurred here in the fourth position. We have a wanting being swamped by a Euro. So now wanting is appearing and your sl is perimeter. When such a mutation occurs we call it trans version. So we're going to eliminate the first answer choice as it cannot be true. Now we have that this trans version or her and the mutated sequence lead to the termination of protein synthesis. So protein synthesis stopped. So I stopped coding was reached which is said to be you. A. Which is the second code on that we have here. So this one is being stopped by your cell created as stop coding. When I stopped coding is created. We call this a nonsense mutation. So this is a trans version mutation that led to a nonsense mutation. So the correct answer choice here is going to be answer choice C. So I mean a trans version led to a nonsense mutation occurring forming the stop code on you. A I really hope this video helped you and I hope to see you on the next one

Refer to the genetic coding dictionary to respond to the following:
A base-substitution mutation that altered the sequence shown in part (a) eliminated the synthesis of all but one polypeptide. The altered sequence is shown here:
5'-AUGCAUACCUAUGUGACCCUUGGA-3'
Determine why.

Verified video answer for a similar problem:

Key Concepts

Genetic Code and Codon-Anticodon Relationship

Base-Substitution Mutation Effects

Translation Termination and Polypeptide Synthesis