Explain how the addition of acetyl groups to histones leads to a weaker association of DNA in nucleosomes.

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Hey, everyone. Let's take a look at this question together, which of the following alterations to his stones can cause an increase in transcription. So let's recall what we know about the different alterations to his stones to figure out which one can cause an increase in transcription. So we know that his stones are proteins that package D N A into nuclear zones which form the basic unit of cro metin. And we know that the his stones can be altered by various post translational modifications which include methylation c dilation, phosphor relation, and ubiquity nation. And so these are the types of modifications of his stones that can regulate gene expression by altering the chromosome structure and accessibility of D N A to transcription factors and RNA preliminaries. And so when we're talking about the assimilation of lysine residues on his stones, we often associate it with transcription als activation. Because when the his stones are assimilated, the positive charge on the license residues is neutralized, leading to a more relaxed chroma tin structure, which a more relaxed crow maten structure means more accessibility to the transcription factors. And R N A liberates, which means that the more relaxed chroma tin structure that leads to more accessibility to transcription factors. And RNA preliminaries means that we have an increase in transcription due to the assimilation of the lysine residues on his stones. Thus making answer choice. B the correct answer because we know that his stones which are proteins that package D N A into the nuclear zones, which form the basic unit of chroma tin have four different types of modifications. One of which being assimilation, which causes transcription activation by giving us a more relaxed chroma tin structure that leads to more accessibility to transcription factors and RNA polymerase which then leads to that increase in transcription. So answer choice B, assimilation of lysine residues is the correct answer to which of the following alterations to his stones can cause that increase in transcription. As opposed to answer choice D which says D assimilation of lysine residues, which the d assimilation of lysine residues is associated with inscription repression, which causes a decrease in transcription and not an increase that we see with assimilation. I hope you found this video to be helpful. Thank you and goodbye.

Explain how the addition of acetyl groups to histones leads to a weaker association of DNA in nucleosomes.

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Key Concepts

Histone Acetylation

Nucleosome Structure

Chromatin Remodeling