Textbook Question
What are the differences and similarities among the three classes of monoallelic gene expression?
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Ch. 19 - Epigenetics
Klug12th EditionConcepts of Genetics ISBN: 9780135564776
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Table of contents
- Ch. 1 - Introduction to Genetics17
- Ch. 2 - Mitosis and Meiosis36
- Ch. 3 - Mendelian Genetics51
- Ch. 4 - Extensions of Mendelian Genetics74
- Ch. 5 - Chromosome Mapping in Eukaryotes51
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages46
- Ch. 7 - Sex Determination and Sex Chromosomes33
- Ch. 8 - Chromosome Mutations: Variation in Number and Arrangement40
- Ch. 9 - Extranuclear Inheritance31
- Ch. 10 - DNA Structure and Analysis43
- Ch. 11 - DNA Replication and Recombination44
- Ch. 12 - DNA Organization in Chromosomes30
- Ch. 13 - The Genetic Code and Transcription54
- Ch. 14 - Translation and Proteins47
- Ch. 15 - Gene Mutation, DNA Repair, and Transposition41
- Ch. 16 - Regulation of Gene Expression in Bacteria29
- Ch. 17 - Transcriptional Regulation in Eukaryotes41
- Ch. 18 - Post-transcriptional Regulation in Eukaryotes33
- Ch. 19 - Epigenetics33
- Ch. 20 - Recombinant DNA Technology44
- Ch. 21 - Genomic Analysis36
- Ch. 22 - Applications of Genetic Engineering and Biotechnology36
- Ch. 23 - Developmental Genetics37
- Ch. 24 - Cancer Genetics34
- Ch. 25 - Quantitative Genetics and Multifactorial Traits54
- Ch. 26 - Population and Evolutionary Genetics45
Chapter 19, Problem 16
Should fertility clinics be required by law to disclose that some assisted reproductive technologies (ARTs) can result in epigenetic diseases? How would you and your partner balance the risks of ART with the desire to have a child?
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Discuss the role of epigenetics in development and how ARTs might influence epigenetic changes.
Explain what epigenetic diseases are and how they can potentially arise from ARTs.
Consider the ethical implications of disclosing potential risks associated with ARTs to prospective parents.
Evaluate the importance of informed consent and how it applies to the use of ARTs.
Discuss strategies for balancing the risks of ART with the desire to have a child, such as consulting with genetic counselors or considering alternative options.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Assisted Reproductive Technologies (ART)
Assisted Reproductive Technologies (ART) encompass a range of medical procedures used to address infertility. These include in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and embryo transfer. ART aims to enhance the chances of conception by manipulating eggs, sperm, or embryos outside the body, making it crucial for couples facing fertility challenges.
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Epigenetics
Epigenetics refers to the study of changes in gene expression that do not involve alterations to the underlying DNA sequence. These changes can be influenced by environmental factors, lifestyle, and certain medical interventions, including ART. Understanding epigenetics is essential for recognizing how assisted reproductive technologies might impact the health of offspring, potentially leading to epigenetic diseases.
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Informed Consent
Informed consent is a fundamental ethical principle in medical practice, requiring that patients are fully informed about the risks, benefits, and alternatives of a procedure before agreeing to it. In the context of ART, this means that fertility clinics should disclose potential risks, including the possibility of epigenetic diseases, allowing couples to make educated decisions about their reproductive options.
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Related Practice
Textbook Question
What is the role of imprinting in human genetic disorders?
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Textbook Question
Imprinting disorders do not involve changes in DNA sequence, but only the methylated state of the DNA. Does it seem likely that imprinting disorders could be treated by controlling the maternal environment in some way, perhaps by dietary changes?
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How can the role of epigenetics in cancer be reconciled with the idea that cancer is caused by the accumulation of genetic mutations in tumor-suppressor genes and proto-oncogenes?
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How are mutations in histone acetylation (HAT) genes linked to cancer?
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A developmental disorder in humans called spina bifida is a neural tube defect linked to a maternal diet low in folate during pregnancy.
What does this suggest about the cause of spina bifida?
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