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Ch. 7 - Sex Determination and Sex Chromosomes
Klug - Concepts of Genetics  12th Edition
Klug12th EditionConcepts of Genetics ISBN: 9780135564776Not the one you use?Change textbook
Chapter 7, Problem 11

When cows have twin calves of unlike sex (fraternal twins), the female twin is usually sterile and has masculinized reproductive organs. This calf is referred to as a freemartin. In cows, twins may share a common placenta and thus fetal circulation. Predict why a freemartin develops.

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Understand that in cattle, when twins of unlike sex (a male and a female) share a common placenta, their blood circulations can mix through shared blood vessels.
Recognize that the male twin produces male hormones (androgens) such as testosterone during development, which can enter the female twin's bloodstream via the shared circulation.
Know that exposure to these male hormones during critical periods of fetal development can interfere with the normal development of the female reproductive system.
Realize that this hormonal influence causes the female twin to develop masculinized reproductive organs and results in sterility, a condition known as freemartinism.
Conclude that the freemartin develops because the female fetus is exposed to male hormones from her male twin through the shared placental blood supply, disrupting normal female reproductive development.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Freemartinism and Sexual Differentiation

Freemartinism occurs when a female calf develops masculinized traits due to exposure to male hormones during fetal development. This happens in mixed-sex twins sharing blood circulation, where male hormones influence the female twin's reproductive system, leading to sterility and masculinization.
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Placental Blood Sharing in Twins

In cattle, fraternal twins often share a common placenta, allowing their blood systems to connect. This shared circulation enables the transfer of hormones and cells between fetuses, which can cause hormonal influence from the male twin to affect the female twin's development.
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Role of Androgens in Reproductive Organ Development

Androgens, such as testosterone, are male sex hormones responsible for developing male reproductive organs. When a female fetus is exposed to these hormones in utero, her reproductive organs can become masculinized, disrupting normal female development and causing sterility.
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Related Practice
Textbook Question

Describe how nondisjunction in human female gametes can give rise to Klinefelter and Turner syndrome offspring following fertilization by a normal male gamete.

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Textbook Question

An insect species is discovered in which the heterogametic sex is unknown. An X-linked recessive mutation for reduced wing (rw) is discovered. Contrast the F1 and F2 generations from a cross between a female with reduced wings and a male with normal-sized wings when the female is the heterogametic sex.

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Textbook Question

An insect species is discovered in which the heterogametic sex is unknown. An X-linked recessive mutation for reduced wing (rw) is discovered. Contrast the F1 and F2 generations from a cross between a female with reduced wings and a male with normal-sized wings when the male is the heterogametic sex.

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Textbook Question

An attached-X female fly, XXY, expresses the recessive X-linked white-eye mutation. It is crossed to a male fly that expresses the X-linked recessive miniature-wing mutation. Determine the outcome of this cross in terms of sex, eye color, and wing size of the offspring.

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Textbook Question

Assume that on rare occasions the attached X chromosomes in female gametes become unattached. Based on the parental phenotypes in Problem 12, what outcomes in the F₁ generation would indicate that this has occurred during female meiosis?

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Textbook Question

It has been suggested that any male-determining genes contained on the Y chromosome in humans cannot be located in the limited region that synapses with the X chromosome during meiosis. What might be the outcome if such genes were located in this region?

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