Human Physiology: An Integrated Approach, 9th edition

Published by Pearson (August 6, 2025) © 2026
Dee Unglaub Silverthorn

Title overview

For courses in human physiology.

A McGuffey Award winner

Human Physiology: An Integrated Approach moves students beyond memorization, helping them construct a global view of the body, its systems, and the many processes that keep the systems working. Silverthorn builds on her active learning instruction style and integrates big-picture themes with the most current cellular and molecular physiology topics.

The 9th Edition now highlights core physiology concepts with openers that preview the chapters in each unit to help students make connections, and provides new Visual Summaries for each chapter. Updated and added discussion and research are incorporated throughout, and a new correlation guide is provided in instructor resources to align with the recent HAPS Physiology Learning Outcomes for Human Physiology.

Hallmark features of this title 

  • Core Concepts of Physiology and their icons are introduced in Chapter 1, and are featured in every subsequent chapter to help students learn the repeating themes that occur throughout the body systems.
  • Visual Summaries replace written synopses at the end of each chapter, offering a clear, quick overview of key concepts with links to detailed discussions. They serve as effective advance organizers to introduce a chapter or reinforce key points at the end of a chapter.
  • Running Problems explore a real-world disease or disorder throughout the chapter. Students check their understanding by comparing their answers with the Problem Conclusion at the end of the chapter.
  • Figure Questions and Graph Questions challenge students to apply what they are learning and build visualization and graphing skills. In the print textbook, answers are provided in Appendix A; in the available Pearson+ eTextbook, answers appear below the figures for immediate feedback.
  • Concept Checks are embedded throughout each chapter to assess understanding before students move forward. In the available Pearson+ eTextbook, answer feedback is provided for each question.

New and updated features of this title

  • More prominent treatment of the immune system relocates coverage to Chapter 7; material has been rewritten to highlight its role as the third control system, coordinating with the nervous and endocrine systems through chemical signals. This change reflects that the pathophysiology of COVID-19 alerted biomedical scientists to how the immune system influences body functions in ways not realized previously.
  • Content and research updated or added in this edition include extracellular vesicles, organoids, newly identified airway epithelial cells, glymphatics, branching sarcomeres, loss of taste and smell in COVID-19, sex as a biological variable, and much more.
  • Unit openers now focus on core physiology concepts that highlight the start of the 4 text units (Core Concepts in Physiology; Homeostasis, Communication, and Control; Integration of Function; Metabolism, Growth, and Reproduction). The 8 selected core concepts are introduced and discussed in Unit 1, then become a unifying theme throughout the remaining chapters.
    • A brief introduction to featured core concepts now begins each chapter. Core concept icons on many pieces of art challenge students to find the core concept represented.
  • Visual summaries with brand-new art replace the text chapter summaries and provide a quick review of key ideas covered in the chapter.
  • Learning Outcomes driven by the new HAPS Physiology Learning Outcomes for Human Physiology are incorporated. As there can be tremendous variability in how introductory physiology is taught, a correlation guide between book learning outcomes for this revision and the HAPS Physiology is available within the Instructor Resources.

Key features

Features of Pearson+ eTextbook for the 9th Edition

  • eText-focused revision maximizes the interactive features only available in the eText:
    • Show/hide features provide the answers to Figure, Graph, and Concept Check questions for a just in time knowledge check
    • Key words have popup definitions, and the links for quick review of topics covered earlier take readers to that content.
  • Over 50 embedded animations and videos, expanded in this revision, bring A&P concepts to life featuring A&P Flix, Interactive Physiology, Physiology in Action and more.
  • New Quick Reference: Pearson+ eTextbook Integrated Media by Chapter is an easy reference of the animations and videos available for each chapter.
  • The new Hot Topics in Physiology brings to the eText author-written articles on new research and happenings in the field. New or revised articles offer posts with exciting news and updates that help students relate core content to the world around them without the need for a new edition.
  • New AI Study Tool pulls from vetted Pearson content to help students achieve proficiency and master key course concepts. Our generative AI chat tool goes beyond a one-size-fits-all approach to provide individualized support, practice and feedback that meet the unique needs of every learner.

Features of Mastering A&P for the 9th Edition

  • Pearson Interactive Labs for A&P immerse students in a virtual wet lab that closely simulates a real lab experience and provides instructors with the flexibility to customize the labs to complement or fully substitute in-person wet labs.
  • Interactive Reading Assignments let students read, watch and practice in one seamless experience. Instructors can now assign specific sections of the eTextbook plus coaching and drag and drop assignments, Dynamic Study Modules, and more for auto-grading.
  • PhysioEx 10.0 is a virtual physiology practice tool that features over 60 easy-to-use lab simulation activities that complement or replace wet labs. Activities help students prepare for and get the most out of lab time.
  • Interactive Physiology 2.0 helps students advance beyond memorization to a genuine understanding of the toughest A&P topics, and is fully accessible on all mobile devices. I.P. 2.0 tutorials are assignable as coaching activities.
  • Teaching Strategies for Active Learning includes over 40 hands-on activities on key topics from thought leaders across the country. Each activity is tied to HAPS Learning Outcomes.
  • Dynamic Study Modules reflect new content and now include shadow questions to prevent students from memorizing questions. Gap Finder: A&P Diagnostic assesses prerequisite knowledge in 5 areas: Study Skills, Math, Chemistry, Cell Biology and Biology Basics.

Table of contents

I. Basic Cell Processes: Integration and Coordination

  • 1. Introduction to Physiology
  • 2. Molecular Interaction
  • 3. Compartmentation: Cells and Tissues
  • 4. Energy and Cellular Metabolism
  • 5. Membrane Dynamics
  • 6. Communication, Integration, and Homeostasis

II. Homeostasis and Control

  • 7. The Immune System
  • 8. Introduction to the Endocrine System
  • 9. Neurons: Cellular and Network Properties
  • 10. The Central Nervous System
  • 11. Sensory Physiology
  • 12. Efferent Division: Autonomic and Somatic Motor Control
  • 13. Muscles
  • 14. Integrative Physiology I: Control of Body Movement

III. Integration of Function

  • 15. Cardiovascular Physiology
  • 16. Blood Flow and the Control of Blood Pressure
  • 17. Blood 18. Mechanics of Breathing
  • 19. Gas Exchange and Transport
  • 20. The Kidneys
  • 21. Integrative Physiology II: Fluid and Electrolyte Balance

IV. Metabolism, Growth, and Aging

  • 22. The Digestive System
  • 23. Metabolism and Energy Balance
  • 24. Endocrine Control of Growth and Metabolism
  • 25. Integrative Physiology III: Exercise
  • 26. Reproduction and Development

Author bios

About our author

Dee Unglaub Silverthorn studied biology as an undergraduate at Newcomb College of Tulane University, where she did research on cockroaches. For graduate school, she switched to studying crabs and received a PhD in marine science from the Belle W. Baruch Institute for Marine and Coastal Sciences at the University of South Carolina. Her research interest is epithelial transport in systems ranging from the crab gill to the chick allantoic membrane.

Dr. Dee has taught in a variety of settings, from medical schools (Medical University of South Carolina, Dell Medical School, UT-Austin) to high school. For most of her career, at the University of Texas - Austin, she has taught undergraduate and graduate physiology lectures and labs, and she trains graduate students to develop teaching skills in the life sciences. Dr. Dee has received numerous teaching awards and honors, including a UT System Regents’ Outstanding Teaching Award, the American Physiological Society (APS) Arthur C. Guyton Physiology Educator of the Year, and multiple UT–Austin awards, including the Burnt Orange Apple Award.

Dr. Dee is past president of the APS (2022-23) and the Human Anatomy and Physiology Society (2012–2013), She has served as editor-in-chief of Advances in Physiology Education and is currently an associate editor. She works with members of the International Union of Physiological Sciences to improve physiology education globally, and this book has been translated into 7 languages. Her free time is spent creating multimedia fiber art, gardening, and enjoying the Texas hill country with her husband, Andrew, and their dogs.

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