Concepts of Genetics, 6th edition

  • William S. Klug
  • Michael R. Cummings

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Overview

Geneticists have long been intrigued as to how several meters of DNA are packed into the eukaryotic nucleus. The discovery of nucleosomes has provided significant insights into this question.

The cover illustration depicts the X-ray crystal structure of the nucleosome core particle at a resolution of 2.8 ÅA. The nucleosome is an integral part of the structure of eukaryotic chromatin. The double-helical ribbon represents 146 base pairs of DNA surrounding four pairs of histone proteins. The nucleosome core particle is repeated over and over in the chromatin fiber and is the principal packaging unit of DNA in the nucleus.

Table of contents

I. HEREDITY AND THE PHENOTYPE.

1. An Introduction to Genetics.

2. Mitosis and Meiosis.

3. Mendelian Genetics.

4. Extensions of Mendelian Genetics.

5. Quantitative Genetics.

6. Linkage, Crossing Over, and Mapping in Eukaryotes.

7. Genetic Recombination and Mapping in Bacteria and Bacteriophages.

8. Extrachromosomal Inheritance.

9. Sex Determination and Sex Chromosomes.

10. Chromosome Mutations: Variations in Chromosome Number and Arrangement.

II. MOLECULAR BASIS OF HEREDITY.

11. DNA Structure and Analysis.

12. DNA Replication and Recombination.

13. The Genetic Code and Transcription.

14. Translation and Proteins.

15. Regulation of Gene Expression in Prokaryotes.

16. Regulation of Gene Expression in Eukaryotes.

17. Gene Mutation, DNA Repair, and Transposable Elements.

III. GENOMICS.

18. Construction and Analysis of DNA Clones.

19. Chromosome Structure and DNA Sequence Organization.

20. Organization of Genes in Chromosomes.

21. Applications and Ethics of Genetic Technology.

IV. GENETICS OF ORGANISMS AND POPULATIONS.

22. Developmental Genetics.

23. Genetics and Cancer.

24. Genetics and Behavior.

25. Population Genetics.

26. Genetics and Evolution.

Published by Benjamin Cummings (August 3rd 1999) - Copyright © 2000