Multiple Choice
In the context of human genetic variation, what type of mutation in the HBB gene causes sickle cell disease?
4. DNA, Chromosomes, and Genomes
Human Genetic Variation
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In the context of human genetic variation, what type of mutation causes sickle cell anemia (HbS) in the HBB gene?
A
A nonsense mutation that introduces a premature stop codon in β-globin
B
A large chromosomal deletion removing the HBB gene
C
A missense point mutation (single-nucleotide substitution) that changes one amino acid in β-globin
D
A frameshift mutation caused by a single-nucleotide insertion in HBB
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