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Multiple Choice
In adaptive immunity, what event most directly initiates activation of a naïve T cell?
A
Binding of soluble antigen directly to the T-cell receptor without antigen presentation
B
Complement activation leading to membrane attack complex formation on the T-cell membrane
C
Engagement of the T-cell receptor (TCR) with a specific peptide presented on MHC molecules of an antigen-presenting cell, along with required co-stimulatory signaling (e.g., CD28 binding B7)
D
Recognition of pathogen-associated molecular patterns by Toll-like receptors on the T cell alone