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Ch.17 Nucleic Acids and Protein Synthesis
Timberlake - Chemistry: An Introduction to General, Organic, and Biological Chemistry 13th Edition
Timberlake13th EditionChemistry: An Introduction to General, Organic, and Biological ChemistryISBN: 9780134421353Not the one you use?Change textbook
Chapter 17, Problem 118

 A polypeptide contains 36 amino acids. How many nucleotides would be found in the mRNA for this polypeptide?

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1
Understand the relationship between amino acids and codons: Each amino acid in a polypeptide is encoded by a codon, which is a sequence of three nucleotides in the mRNA.
Determine the total number of codons required: Since the polypeptide contains 36 amino acids, there will be 36 codons in the mRNA, as each codon corresponds to one amino acid.
Account for the start and stop codons: In addition to the codons for the amino acids, the mRNA will also include a start codon (to initiate translation) and a stop codon (to terminate translation). This adds 2 more codons to the total count.
Calculate the total number of nucleotides: Multiply the total number of codons (36 amino acid codons + 1 start codon + 1 stop codon = 38 codons) by 3 nucleotides per codon. Use the formula: Total=38×3.
Conclude the calculation: The result of the multiplication will give the total number of nucleotides in the mRNA for the polypeptide.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Amino Acids and Polypeptides

Amino acids are the building blocks of proteins, and when linked together, they form polypeptides. Each polypeptide is a specific sequence of amino acids that determines the protein's structure and function. In this context, a polypeptide containing 36 amino acids indicates that it is composed of a specific arrangement of these building blocks.
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mRNA and Codons

Messenger RNA (mRNA) is a type of RNA that conveys genetic information from DNA to the ribosome, where proteins are synthesized. Each amino acid in a polypeptide is encoded by a sequence of three nucleotides called a codon. Therefore, to determine the number of nucleotides in the mRNA, one must consider that each amino acid corresponds to one codon, which consists of three nucleotides.
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Transcription: mRNA Synthesis Concept 1

Nucleotide Calculation

To find the total number of nucleotides in the mRNA for a polypeptide, multiply the number of amino acids by three, as each amino acid is represented by a codon of three nucleotides. For a polypeptide with 36 amino acids, the calculation would be 36 amino acids multiplied by 3 nucleotides per codon, resulting in a total of 108 nucleotides in the mRNA.
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