True or False:Gluconeogenesis occurs in the exact reverse as glycolysis.

• A. True
• B. False

Answer: (B)

Verified step by step guidance

1. Understand the processes: Glycolysis is the metabolic pathway that converts glucose into pyruvate, releasing energy and forming ATP. Gluconeogenesis is the process of synthesizing glucose from non-carbohydrate precursors, essentially the reverse of glycolysis in terms of end products.
2. Identify the key differences: While gluconeogenesis and glycolysis share some enzymes, they are not exact reverses of each other. There are three irreversible steps in glycolysis that require different enzymes in gluconeogenesis.
3. Examine the irreversible steps: In glycolysis, the conversion of glucose to glucose-6-phosphate, fructose-6-phosphate to fructose-1,6-bisphosphate, and phosphoenolpyruvate to pyruvate are irreversible. Gluconeogenesis bypasses these steps using different enzymes.
4. Explore the bypass reactions: In gluconeogenesis, the conversion of pyruvate to phosphoenolpyruvate involves two steps using pyruvate carboxylase and phosphoenolpyruvate carboxykinase. Fructose-1,6-bisphosphate is converted to fructose-6-phosphate by fructose-1,6-bisphosphatase, and glucose-6-phosphate is converted to glucose by glucose-6-phosphatase.
5. Conclude the analysis: Since gluconeogenesis uses different enzymes for the irreversible steps of glycolysis and involves additional steps, it is not the exact reverse of glycolysis. Therefore, the statement is false.