Multiple Choice
In the context of translation, what is the primary function of ribosomes in a cell?
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5. DNA to RNA to Protein
Translation
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In translation, how does the ribosome know when to stop synthesizing a polypeptide?
A
The ribosome stops when the A site binds a tRNA carrying tryptophan, because tryptophan is the final amino acid in most proteins.
B
A stop codon (UAA, UAG, or UGA) enters the A site and is recognized by a release factor, which triggers hydrolysis of the polypeptide from the tRNA.
C
The ribosome stops when the Shine-Dalgarno sequence is reached, because it signals termination of elongation.
D
The ribosome stops when GTP is depleted, because elongation cannot proceed without GTP hydrolysis.
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