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Ch. 1 - Introduction to Microbiology
Norman-McKay- Microbiology: Basic and Clinical Principles 2nd Edition
Norman-McKay2nd EditionMicrobiology: Basic and Clinical PrinciplesISBN: 9780137661619Not the one you use?Change textbook
Chapter 1, Problem 20

Acid-fast bacteria contain ___________________ in their cell wall.

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1
Understand that acid-fast bacteria are a group of bacteria characterized by their unique cell wall composition, which allows them to retain certain stains even after being washed with acid-alcohol.
Recall that the key component responsible for this acid-fast property is a type of lipid found in their cell wall.
Identify that this lipid is called mycolic acid, a long-chain fatty acid that makes the cell wall waxy and hydrophobic.
Recognize that mycolic acid is the reason acid-fast bacteria resist decolorization by acid-alcohol during staining procedures like the Ziehl-Neelsen stain.
Conclude that acid-fast bacteria contain mycolic acid in their cell wall.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Acid-Fast Bacteria

Acid-fast bacteria are a group of bacteria that resist decolorization by acids during staining procedures. This property is due to the unique composition of their cell walls, which makes them distinguishable from non-acid-fast bacteria in microbiological tests.
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Mycolic Acid

Mycolic acid is a long-chain fatty acid found in the cell walls of acid-fast bacteria. It creates a waxy, hydrophobic layer that protects the bacteria from chemical damage and dehydration, and is responsible for their acid-fast staining characteristics.
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Cell Wall Structure in Bacteria

Bacterial cell walls provide shape and protection. In acid-fast bacteria, the cell wall contains a thick layer of mycolic acid linked to peptidoglycan, which differs from typical Gram-positive or Gram-negative bacteria and influences staining and antibiotic susceptibility.
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Introduction to Bacterial Cell Walls