Indicate whether each statement is true or false. If the statement is false, change the underlined word or phrase to make the statement true.
______Graft-versus-host disease can follow a bone marrow isograft.

Verified step by step guidance

1. Understand the key terms: A bone marrow isograft is a transplant between genetically identical individuals, such as identical twins.
2. Recall that graft-versus-host disease (GVHD) occurs when donor immune cells attack the recipient's tissues, which typically happens when there is genetic disparity between donor and recipient.
3. Since isografts involve genetically identical donors and recipients, the immune cells recognize the host as 'self' and do not attack, making GVHD unlikely.
4. Therefore, the statement 'Graft-versus-host disease can follow a bone marrow isograft' is false.
5. To correct the statement, replace 'isograft' with 'allograft,' because GVHD commonly follows bone marrow allografts, where donor and recipient are genetically different.

Key Concepts

Graft-versus-Host Disease (GVHD)

GVHD is a condition where donor immune cells attack the recipient's tissues after a transplant. It commonly occurs after allogeneic transplants, where the donor and recipient are genetically different, leading to immune incompatibility.

Bone Marrow Isograft

An isograft is a transplant between genetically identical individuals, such as identical twins. Because the donor and recipient share the same genetic makeup, immune rejection and GVHD are highly unlikely in isografts.

Types of Bone Marrow Transplants

Bone marrow transplants can be autografts (self), isografts (identical twin), or allografts (genetically different donor). GVHD typically occurs only in allografts due to immune differences, not in autografts or isografts.