A proposed strategy for combatting the spread of antibiotic resistance is to allow doctors to prescribe only a certain subset of antibiotic drugs and regularly rotate which antibiotics are allowed to be prescribed over several years. Why could this approach limit the spread of antibiotic resistance?

• A. Using different antibiotics at different times will prevent your body from developing too strong a resistance to any one drug.
• B. During times when a specific antibiotic is NOT being used, those bacteria with resistance will not have higher fitness and are more likely to be removed from the population.
• C. Removing the use of certain antibiotics lessens the chance that bacterial genomes will mutate in ways that provide resistance to that specific antibiotic.
• D. This approach would allow bacteria to evolve resistance to less powerful and, therefore, less important drugs while keeping resistance low to more powerful and important antibiotics.

Answer: (B)