Several weight loss medications target the receptors for which of the following hormones, thereby lowering hunger and increasing satiety?

• A. Thyroxine.
• B. CCK.
• C. Leptin.
• D. GLP-1.

Answer: (D)

Verified step by step guidance

1. Understand the role of hormones in regulating hunger and satiety. Hormones like GLP-1 (Glucagon-like peptide-1), CCK (Cholecystokinin), leptin, and thyroxine play different roles in appetite and metabolism.
2. Review the function of GLP-1. GLP-1 is a hormone secreted by the intestines in response to food intake. It promotes satiety (feeling of fullness) and reduces hunger by acting on the brain's appetite centers and slowing gastric emptying.
3. Compare GLP-1 with the other hormones listed: Thyroxine is a thyroid hormone that regulates metabolism but does not directly influence hunger or satiety. CCK is involved in digestion and signals satiety but is not a primary target for weight loss medications. Leptin is a hormone produced by fat cells that regulates long-term energy balance but is less commonly targeted by medications.
4. Recognize that many weight loss medications mimic or enhance the effects of GLP-1 to reduce hunger and increase satiety. These medications are often referred to as GLP-1 receptor agonists.
5. Conclude that the correct answer is GLP-1, as it is the hormone most directly targeted by weight loss medications to lower hunger and increase satiety.