Multiple Choice
Which enzyme creates nicks ahead of the replication fork to relieve tension from DNA unwinding during replication?
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17. Mutation, Repair, and Recombination
DNA Repair
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In the context of DNA repair during replication, which mechanism most directly helps prevent errors in DNA replication by removing misincorporated nucleotides as DNA is being synthesized?
A
Telomerase extending chromosome ends to prevent shortening
B
DNA ligase sealing nicks between Okazaki fragments
C
Topoisomerase relieving supercoiling ahead of the replication fork
D
3′→5′ exonuclease proofreading activity of DNA polymerase
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