Which of the following statements are true regarding chloride?
I. Functions as a buffer in blood.
II. Major intracellular electrolyte.
III. Deficiency is rare but can be caused by dehydration.

• A. I & II.
• B. I & III.
• C. II & III.
• D. I, II,& III.

Answer: (B)

Verified step by step guidance

1. Step 1: Understand the role of chloride in the body. Chloride is an essential electrolyte that helps maintain fluid balance, contributes to the production of stomach acid (HCl), and plays a role in acid-base balance as a buffer in the blood.
2. Step 2: Analyze statement I: 'Functions as a buffer in blood.' This is true because chloride helps maintain acid-base balance by participating in the chloride-bicarbonate exchange system, which regulates pH levels in the blood.
3. Step 3: Analyze statement II: 'Major intracellular electrolyte.' This is false because chloride is primarily an extracellular electrolyte, meaning it is found in higher concentrations outside of cells rather than inside.
4. Step 4: Analyze statement III: 'Deficiency is rare but can be caused by dehydration.' This is true because chloride deficiency (hypochloremia) is uncommon but can occur due to excessive fluid loss, such as from dehydration, vomiting, or diarrhea.
5. Step 5: Based on the analysis, determine which combination of statements is correct. Statements I and III are true, while statement II is false. Therefore, the correct answer is 'I & III.'