1. Intro to Stats and Collecting Data

Grouping together similar experimental units and then randomly assigning the experimental units within each group to a treatment is called .

"[NW] Chew Your Food Researchers wanted to determine the association between number of times one chews food and food consumption. They identified 45 individuals who were 18 to 45 years of age. First, the researchers determined a baseline for number of chews before swallowing food. Next, each participant attended three sessions to eat pizza for lunch until comfortably full by chewing each portion of food 100%, 150%, and 200% of their baseline number of chews before swallowing. Food intake for each of the three chewing treatments was then measured. It was found that food consumption was reduced significantly, by 9.5% and 14.8%, respectively, for the 150% and 200% number of chews compared to the baseline. Source: Yong Zhu and James H. Hollis. “Increasing the Number of Chews before Swallowing Reduces Meal Size in Normal-Weight, Overweight, and Obese Adults,” Journal of the Academy of Nutrition and Dietetics, 11 November 2013.

What is the research objective of the study?"

"[NW] Chew Your Food Researchers wanted to determine the association between number of times one chews food and food consumption. They identified 45 individuals who were 18 to 45 years of age. First, the researchers determined a baseline for number of chews before swallowing food. Next, each participant attended three sessions to eat pizza for lunch until comfortably full by chewing each portion of food 100%, 150%, and 200% of their baseline number of chews before swallowing. Food intake for each of the three chewing treatments was then measured. It was found that food consumption was reduced significantly, by 9.5% and 14.8%, respectively, for the 150% and 200% number of chews compared to the baseline. Source: Yong Zhu and James H. Hollis. “Increasing the Number of Chews before Swallowing Reduces Meal Size in Normal-Weight, Overweight, and Obese Adults,” Journal of the Academy of Nutrition and Dietetics, 11 November 2013.

How is control used in this study?"

"Alcohol Dependence To determine if topiramate is a safe and effective treatment for alcohol dependence, researchers conducted a 14-week trial of 371 men and women aged 18 to 65 years diagnosed with alcohol dependence. In this double-blind, randomized, placebo-controlled experiment, subjects were randomly given either 300 milligrams (mg) of topiramate (183 subjects) or a placebo (188 subjects) daily, along with a weekly compliance enhancement intervention. The variable used to determine the effectiveness of the treatment was self-reported percentage of heavy drinking days. Results indicated that topiramate was more effective than placebo at reducing the percentage of heavy drinking days. The researchers concluded that topiramate is a promising treatment for alcohol dependence. Source: Bankole A. Johnson, Norman Rosenthal, et al. “Topiramate for Treating Alcohol Dependence: A Randomized Controlled Trial,” Journal of the American Medical Association, 298(14):1641–1651, 2007.

What does it mean for the experiment to be placebo-controlled?"

"Alcohol Dependence To determine if topiramate is a safe and effective treatment for alcohol dependence, researchers conducted a 14-week trial of 371 men and women aged 18 to 65 years diagnosed with alcohol dependence. In this double-blind, randomized, placebo-controlled experiment, subjects were randomly given either 300 milligrams (mg) of topiramate (183 subjects) or a placebo (188 subjects) daily, along with a weekly compliance enhancement intervention. The variable used to determine the effectiveness of the treatment was self-reported percentage of heavy drinking days. Results indicated that topiramate was more effective than placebo at reducing the percentage of heavy drinking days. The researchers concluded that topiramate is a promising treatment for alcohol dependence. Source: Bankole A. Johnson, Norman Rosenthal, et al. “Topiramate for Treating Alcohol Dependence: A Randomized Controlled Trial,” Journal of the American Medical Association, 298(14):1641–1651, 2007.

What does it mean for the experiment to be double-blind? Why do you think it is necessary for the experiment to be double-blind?"

"School Psychology A school psychologist wants to test the effectiveness of a new method for teaching reading. She recruits 500 first-grade students in District 203 and randomly divides them into two groups. Group 1 is taught by means of the new method, while group 2 is taught by traditional methods. The same teacher is assigned to teach both groups. At the end of the year, an achievement test is administered and the results of the two groups are compared.

What is the response variable in this experiment?"

"School Psychology A school psychologist wants to test the effectiveness of a new method for teaching reading. She recruits 500 first-grade students in District 203 and randomly divides them into two groups. Group 1 is taught by means of the new method, while group 2 is taught by traditional methods. The same teacher is assigned to teach both groups. At the end of the year, an achievement test is administered and the results of the two groups are compared.

What type of experimental design is this?"

"School Psychology A school psychologist wants to test the effectiveness of a new method for teaching reading. She recruits 500 first-grade students in District 203 and randomly divides them into two groups. Group 1 is taught by means of the new method, while group 2 is taught by traditional methods. The same teacher is assigned to teach both groups. At the end of the year, an achievement test is administered and the results of the two groups are compared.

Explain how time of day the course is taught could potentially confound the results of the study. Can anything be done to eliminate the effect of this confounding variable?"

"Pharmacy A pharmaceutical company has developed an experimental drug meant to relieve symptoms associated with the common cold. The company identifies 300 adult males 25 to 29 years old who have a common cold and randomly divides them into two groups. Group 1 is given the experimental drug, while group 2 is given a placebo. After 1 week of treatment, the subjects report whether they still have cold symptoms, or not.

Think of some of the factors in the study. How are they controlled?"

Daily Coffee Consumption Is there an association between daily coffee consumption and the occurrence of skin cancer? Researchers asked 93,676 women to disclose their coffee-drinking habits and also determined which of the women had nonmelanoma skin cancer. The researchers concluded that consumption of six or more cups of caffeinated coffee per day was associated with a reduction in nonmelanoma skin cancer. Source: European Journal of Cancer Prevention, 16(5): 446–452, October 2007.

What is the response variable in the study? What is the explanatory variable?

[NW] Television in the Bedroom Is a television (TV) in the bedroom associated with obesity? Researchers questioned 379 twelve-year old adolescents and concluded that the body mass index (BMI) of the adolescents who had a TV in their bedroom was significantly higher than the BMI of those who did not have a TV in their bedroom. Source: Christelle Delmas, Carine Platat, Brigitte Schweitzer, Aline Wagner, Mohamed Oujaa, and Chantal Simon. “Association Between Television in Bedroom and Adiposity Throughout Adolescence,” Obesity, 15:2495–2503, 2007.

What is the response variable in the study? What is the explanatory variable?

[NW] Television in the Bedroom Is a television (TV) in the bedroom associated with obesity? Researchers questioned 379 twelve-year old adolescents and concluded that the body mass index (BMI) of the adolescents who had a TV in their bedroom was significantly higher than the BMI of those who did not have a TV in their bedroom. Source: Christelle Delmas, Carine Platat, Brigitte Schweitzer, Aline Wagner, Mohamed Oujaa, and Chantal Simon. “Association Between Television in Bedroom and Adiposity Throughout Adolescence,” Obesity, 15:2495–2503, 2007.

c. Can you think of any lurking variables that may affect the results of the study?

[NW] Television in the Bedroom Is a television (TV) in the bedroom associated with obesity? Researchers questioned 379 twelve-year old adolescents and concluded that the body mass index (BMI) of the adolescents who had a TV in their bedroom was significantly higher than the BMI of those who did not have a TV in their bedroom. Source: Christelle Delmas, Carine Platat, Brigitte Schweitzer, Aline Wagner, Mohamed Oujaa, and Chantal Simon. “Association Between Television in Bedroom and Adiposity Throughout Adolescence,” Obesity, 15:2495–2503, 2007.

d. In the report, the researchers stated, “These results remain significant after adjustment for socioeconomic status.” What does this mean?

Midwives Researchers Sally Tracy and associates undertook a cross-sectional study looking at the method of delivery and cost of delivery for first-time “low risk” mothers under three delivery scenarios:

1. Caseload midwifery

2. Standard hospital care

3. Private obstetric care

The results of the study revealed that 58.5% of all births with midwifery were vaginal deliveries compared with 48.2% of standard hospital births and 30.8% of private obstetric care. In addition, the costs of delivery from midwifery was \$3903.78 compared with \$5279.23 for standard hospital care and \$5413.69 for private obstetric care.Source: Sally K Tracy, Alec Welsh, Bev Hall, Donna Hartz, Anne Lainchbury, Andrew Bisits, Jan White, and Mark Tracy “Caseload midwifery compared to standard or private obstetric care for first time mothers in a public teaching hospital in Australia: a cross sectional study of cost and birth outcomes” BMC Pregnancy and Childbirth 2014, 14:46.

b. Name the explanatory variable in the study.

Web Page Design Magnum, LLC, is a web page design firm that has two designs for an online hardware store. To determine which is the more effective design, Magnum uses one page in the Denver area and a second page in the Miami area. For each visit, Magnum records the amount of time visiting the site and the amount spent by the visitor.

c. Explain how confounding might be an issue with this study.