During which phase of mitosis does the separation of sister chromatids occur?

• A. Anaphase
• B. Metaphase
• C. Telophase
• D. Prophase

Answer: (A)

Verified step by step guidance

1. Recall the main phases of mitosis: Prophase, Metaphase, Anaphase, and Telophase.
2. Understand that during Prophase, chromosomes condense and the mitotic spindle begins to form.
3. During Metaphase, chromosomes align at the metaphase plate (center of the cell).
4. In Anaphase, sister chromatids are pulled apart toward opposite poles of the cell, which is the key event of chromatid separation.
5. Finally, Telophase involves the reformation of the nuclear envelope around the separated chromatids, now considered individual chromosomes.