In the context of types of mutations, which mutation is most likely to cause translation to stop prematurely?

• A. An in-frame insertion of three nucleotides that adds one amino acid
• B. A nonsense mutation that changes a sense codon into a stop codon
• C. A missense mutation that changes one amino acid to another
• D. A silent (synonymous) mutation that changes a codon but not the amino acid

Answer: (B)