Lagging strand telomeres are replicated in the same way as the rest of the chromosome

• A. True
• B. False

Answer: (B)

Verified step by step guidance

1. Understand the basic structure of a telomere: Telomeres are repetitive nucleotide sequences at the end of chromosomes that protect them from deterioration or fusion with neighboring chromosomes.
2. Review the replication process of DNA: DNA replication involves the synthesis of a leading strand and a lagging strand. The leading strand is synthesized continuously, while the lagging strand is synthesized in short segments called Okazaki fragments.
3. Examine the replication of telomeres: Telomeres pose a unique challenge during replication because the lagging strand cannot be fully replicated by conventional DNA polymerases, leading to progressive shortening of telomeres with each cell division.
4. Learn about the role of telomerase: Telomerase is an enzyme that adds repetitive nucleotide sequences to the ends of telomeres, counteracting the shortening that occurs during replication. It is particularly active in germ cells, stem cells, and certain cancer cells.
5. Consider the implications of telomere replication: The replication of telomeres is distinct from the rest of the chromosome due to the involvement of telomerase, which is not required for the replication of other chromosomal regions.