Multiple Choice
During DNA replication, what stabilizes the unwound single-stranded DNA to prevent it from reannealing or forming secondary structures?
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8. DNA Replication
Overview of DNA Replication
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In the overview of DNA replication, what is the primary role of topoisomerase at the replication fork?
A
It unwinds the DNA double helix by breaking hydrogen bonds between complementary bases.
B
It synthesizes short RNA primers needed to initiate DNA synthesis on the leading and lagging strands.
C
It relieves torsional strain (supercoiling) ahead of the replication fork by transiently cutting and rejoining DNA strands.
D
It joins Okazaki fragments together by sealing nicks in the sugar-phosphate backbone.
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