RNA polymerase is guided by the:

• A. anticodon loop of tRNA
• B. polyadenylation signal
• C. ribosome binding site
• D. promoter region of the DNA

Answer: (D)

Verified step by step guidance

1. Understand the role of RNA polymerase: RNA polymerase is the enzyme responsible for synthesizing RNA from a DNA template during transcription.
2. Identify what guides RNA polymerase to the correct starting point on the DNA: RNA polymerase does not recognize tRNA anticodon loops, polyadenylation signals, or ribosome binding sites, as these are involved in other processes.
3. Recall that the promoter region of DNA is a specific sequence upstream of a gene where RNA polymerase binds to initiate transcription.
4. Recognize that the promoter contains specific sequences (like the TATA box in eukaryotes) that are recognized by RNA polymerase and associated transcription factors to start RNA synthesis.
5. Conclude that the promoter region of the DNA is the correct answer because it guides RNA polymerase to the correct site to begin transcription.