Which of the following statements about food additives is true?

• A. All additives must be tested for safety by the FDA before they can be added to food.
• B. Some additives that have been used historically do not need to undergo initial safety testing. 
• C. Once something is judged to be safe, it is no longer regulated by the FDA.
• D. All additives are reviewed by the FDA for safety at least once annually.

Answer: (B)

Verified step by step guidance

1. Understand the role of the FDA in regulating food additives: The FDA is responsible for ensuring that food additives are safe for consumption before they are used in foods.
2. Recognize that not all food additives undergo the same regulatory process: Some additives, known as GRAS (Generally Recognized As Safe), have a history of safe use and may not require the same pre-market safety testing as new additives.
3. Identify that additives with a long history of use may be exempt from initial safety testing because their safety is already established through historical data and scientific consensus.
4. Note that even after approval, the FDA continues to monitor food additives for safety, but not necessarily through annual reviews of all additives.
5. Conclude that the true statement is that some additives used historically do not need to undergo initial safety testing, reflecting the GRAS status and FDA regulatory framework.