Which of the following correctly illustrates the pairing between DNA and RNA nucleotides during transcription?

• A. A pairs with U, T pairs with A, C pairs with G, G pairs with C
• B. A pairs with T, T pairs with U, C pairs with G, G pairs with C
• C. A pairs with G, T pairs with C, C pairs with U, G pairs with A
• D. A pairs with C, T pairs with G, C pairs with A, G pairs with U

Answer: (A)

Verified step by step guidance

1. Recall the base pairing rules during transcription, where DNA serves as the template for RNA synthesis.
2. Identify that in DNA, adenine (A) pairs with thymine (T), cytosine (C) pairs with guanine (G), and vice versa.
3. During transcription, RNA nucleotides pair with the DNA template strand, but RNA contains uracil (U) instead of thymine (T).
4. Therefore, adenine (A) in DNA pairs with uracil (U) in RNA, thymine (T) in DNA pairs with adenine (A) in RNA, cytosine (C) pairs with guanine (G), and guanine (G) pairs with cytosine (C).
5. Use these pairing rules to evaluate each option and determine which correctly represents the DNA-RNA nucleotide pairing during transcription.