Centromeres split and sister chromatids are separated from each other only during which phase of mitosis?

• A. Metaphase
• B. Telophase
• C. Prophase
• D. Anaphase

Answer: (D)

Verified step by step guidance

1. Recall the stages of mitosis: Prophase, Metaphase, Anaphase, and Telophase, each with distinct events.
2. Understand that during Prophase, chromosomes condense and the mitotic spindle begins to form, but sister chromatids remain attached.
3. During Metaphase, chromosomes align at the metaphase plate, but sister chromatids are still joined at the centromere.
4. Recognize that Anaphase is the phase where the centromeres split, allowing sister chromatids to separate and move toward opposite poles of the cell.
5. Note that Telophase involves the reformation of the nuclear envelope around the separated chromatids, now considered individual chromosomes.