Multiple Choice
In eukaryotic chromosome structure, what forms the coiled structure made of DNA and proteins that can further condense into visible chromosomes during cell division?
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7. DNA and Chromosome Structure
Eukaryotic Chromosome Structure
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In eukaryotic chromosome structure, why do histones bind tightly to DNA?
A
Histones bind tightly to DNA primarily through sequence-specific base-pair recognition in the major groove, similar to many transcription factors.
B
Histones are rich in positively charged basic amino acids (e.g., lysine and arginine) that electrostatically attract the negatively charged phosphate backbone of DNA.
C
Histones form covalent bonds with the sugar-phosphate backbone of DNA, permanently linking DNA to the nucleosome core.
D
Histones bind tightly because they are negatively charged and therefore repel DNA into a compact structure.
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