13. Gene Regulation in Eukaryotes

What is the role of imprinting in human genetic disorders?

How does an environmental factor like stress generate a response that is transmitted from generation to generation?

Chromosomal regions that form heterochromatin contain:

Which of the following are examples of epigenetic marks?

CpG islands are defined as which of the following?

Which of the following terms is associated with closed chromatin?

What is the evidence that epigenetic changes are involved in cancer?

How do we know how methylation of promoters silences gene expression?

How do we know that microRNAs negatively regulate target mRNAs?

Write a short essay describing how epigenetic changes in cancer cells contribute to the development and maintenance of cancers.

What is meant by the term chromatin remodeling? Describe the importance of this process to transcription.

What are the major mechanisms of epigenetic genome modification?

What general role does acetylation of histone protein amino acids play in the transcription of eukaryotic genes?

Provide a definition of chromatin remodeling, and give two examples of this phenomenon.