Homologous recombinant transgenic mice are usually created using ...

18. Molecular Genetic Tools

Genetic Cloning

18. Molecular Genetic Tools

ANSWERS OPTIONS

ES cells are isolated from developing mice embryos, while gene targeting involves introducing a linear DNA molecule into yeast cells.

Gene targeting is more efficient in mice than in yeast.

ES cells are single-celled fungi, while gene targeting involves the use of embryonic stem cells.

Homologous recombination is generally more efficient in yeast than in mice.

Homologous recombinant transgenic mice are usually created using embryonic stem (ES) cells whereas homologous recombinant yeast is typically created through a process known as gene targeting. Which of the following statements best describes the difference between these processes?