_______________ is a type of transcriptional regulation that lets a single gene produce multiple mRNA isoforms that can be translated into different proteins.

9PRACTICE PROBLEM

Transcription factors are mostly known to bind to which region of the gene locus?

10PRACTICE PROBLEM

Which of the following disorders is caused by a mutation in the SMN1 gene, which is responsible for the production of a protein essential for the maintenance and survival of motor neurons?

11PRACTICE PROBLEM

Which of the following is NOT a cis-acting regulatory DNA sequence?

12PRACTICE PROBLEM

Identify the incorrect statement about silencers.

13PRACTICE PROBLEM

__________ bind to enhancer sequences to regulate the expression of a gene.

14PRACTICE PROBLEM

Identify the incorrect statement about enhancers.

15PRACTICE PROBLEM

A group of enzymes that catalyzes the removal of specific post-transcriptional modifications, resulting in the modulation of gene expression are called:

16PRACTICE PROBLEM

RNA plays a major role in the regulation of gene expression in eukaryotic cells. Which of the following statements regarding the roles of RNA in eukaryotic gene regulation is true?

17PRACTICE PROBLEM

Which of the following statements best describes the distinction between promoters and enhancers in gene regulation?

18PRACTICE PROBLEM

Which of the following types of RNA can modulate chromatin structure, and play important role in epigenetic regulation?

19PRACTICE PROBLEM

The level of transcription can be affected by alternative promoters in the following ways:

20PRACTICE PROBLEM

All of the following are components of the eukaryotic promoter, except:

21PRACTICE PROBLEM

Which of the following consensus sequences is involved in the regulation of the β -globin gene during erythropoiesis and is located approximately 135 base pairs upstream of the transcription start site?

22PRACTICE PROBLEM

Which of the following is not a mechanism of Post-transcriptional gene silencing (PTGS)?

23PRACTICE PROBLEM

Which of the following statements best describes the action of an enhanceosome?

24PRACTICE PROBLEM

Which of the following is a silencer element that regulates gene expression during development?

25PRACTICE PROBLEM

Which one of the following statements accurately describes the function of insulator sequences when they bind to specific proteins?

26PRACTICE PROBLEM

Which of the following statements correctly pairs the role of the upstream activator sequence (UAS) with an example?

27PRACTICE PROBLEM

Which one of the following subunits or domains of dicer is involved in the cleavage of double-stranded RNA?

28PRACTICE PROBLEM

Which of the following small RNA molecules is recognized by RNA-induced silencing complex (RISC) and binds to target mRNA molecules by direct base-pairing?

29PRACTICE PROBLEM

How do silencers work to regulate gene expression?

30PRACTICE PROBLEM

Which of the following statement is incorrect regarding enhancers?

31PRACTICE PROBLEM

Which of the following statement is correct regarding promoter?

32PRACTICE PROBLEM

Identify which of the following is NOT a function of RNA interference.

33PRACTICE PROBLEM

Which of the following statements about RNA interference is correct?

34PRACTICE PROBLEM

Activation of Src protein kinase leads to the localization of actin mRNA to the leading edge of the cell, which is the direction the cell will migrate. Which of the following processes causes the Src protein kinase to be activated?

35PRACTICE PROBLEM

Which of the following is a DNA sequence variation called, SNP (pronounced as a snip) that occurs when a single nucleotide (adenine, thymine, cytosine, or guanine) in the genome sequence is altered?

36PRACTICE PROBLEM

If a non-coding region known as an intron is not removed during the __________ process in mRNA, translation will result in the formation of altered or non-functional proteins.

37PRACTICE PROBLEM

Which of the following techniques is to be used to study the effects of cis-elements on posttranscriptional gene regulation?

38PRACTICE PROBLEM

RNA helicases are essential for separating the self-annealed RNA molecule. They are also essential in most processes of RNA metabolism such as:

39PRACTICE PROBLEM

Which of the following statements about ubiquitin ligase is false?

40PRACTICE PROBLEM

Determine which of the following characteristics is shared by an enhancer and a silencer.

41PRACTICE PROBLEM

Which of the following hormones promotes the transcription of the Human Metallothionein 2A gene under stress conditions?

42PRACTICE PROBLEM

Which of the following best describes why mRNA's position in a cell differs from the intracellular protein it encodes?

43PRACTICE PROBLEM

Which of the following statements is true about alternative polyadenylation?

44PRACTICE PROBLEM

The most prevalent type of alternative splicing where exons are excluded from the mature mRNA is called:

45PRACTICE PROBLEM

The mRNAs stored within the cell in a translationally inactive state are:

46PRACTICE PROBLEM

What function does the 5' cap structure serve in mRNA storage?

47PRACTICE PROBLEM

The cytoplasmic polyadenylation element binding protein (CBEP) is an RBP that recruits proteins to regulate gene expression. One of these proteins is called Maskin. How does Maskin help the CBEP and CPE in maintaining post-transcriptional regulation in eukaryotic cells?

48PRACTICE PROBLEM

Identify the incorrect statement(s) about circular RNA.

49PRACTICE PROBLEM

How do molecular "sponges" affect the control of gene expression?

50PRACTICE PROBLEM

Nonsense-mediated decay is a process of mRNA degradation in eukaryotes that is triggered by the presence of:

51PRACTICE PROBLEM

How does the deadenylation process degrade mRNA?

52PRACTICE PROBLEM

How does alternative splicing regulate gene expression?

53PRACTICE PROBLEM

All of the following are functions of processing bodies (P bodies) in mRNA regulation, except:

54PRACTICE PROBLEM

AU-rich elements (AREs) are sequences of RNA that contain a high percentage of:

55PRACTICE PROBLEM

Which of the following methods enables cells to discriminate between normal mRNAs and those with a premature stop?

56PRACTICE PROBLEM

Enhancers are regions of DNA that work by:

57PRACTICE PROBLEM

Which of the following is an example of a cis-acting regulatory element?

58PRACTICE PROBLEM

Which of the following alterations to histones can cause an increase in transcription?

59PRACTICE PROBLEM

Eukaryotic gene expression is not regulated at the level of:

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