Which of the following options correctly describes the DNA altera...

17. Mutation, Repair, and Recombination

Types of Mutations

17. Mutation, Repair, and Recombination

ANSWERS OPTIONS

A deletion of two nucleotides changes the sequence from 5′-GGTCC-3′ (wild-type) to 5′-GAC-3′ (mutant).

A substitution of one nucleotide changes the sequence from 5′-GGATCC-3′ (wild-type) to 5′-GGAACC-3′ (mutant) .

An insertion of one nucleotide changes the sequence from 5′-GGATCC-3′ (wild-type) to 5′-GGAACTC-3′ (mutant).

A substitution of two nucleotides changes the sequence from 5′-GGATCC-3′ (wild-type) to 5′-GGCTCC-3′ (mutant).

Which of the following options correctly describes the DNA alteration responsible for the Ser-to-Thr missense mutation in the BamHI restriction site of the mutant HAO (homogentisic acid oxidase) gene that causes Alkaptonuria, an autosomal recessive disorder in humans?