20. Adaptive Immunity

Helper T cells respond to antigens from _____ and cytotoxic T cells respond to antigens from _____.

Which of the following cells is capable of specifically responding to a nearly infinite number of epitopes?

A kidney-transplant patient experienced a cytotoxic rejection of the new kidney. Place the following in order for that rejection:

(1) apoptosis occurs

(2) CD8⁺ T cell becomes CTL

(3) granzymes released

(4) MHC class I activates CD8⁺ T cell

(5) perforin released

a. 1, 2, 3, 4, 5

b. 5, 4, 3, 2, 1

c. 4, 2, 5, 3, 1

d. 3, 4, 5, 1, 2

e. 2, 3, 4, 1, 5

What does MHC stand for? What is the function of MHC? What types of T cells interact with MHC class I? With MHC class II?

In what ways do tumor cells differ antigenically from normal cells? Explain how tumor cells may be destroyed by the immune system.

If tumor cells can be destroyed by the immune system, how does cancer develop? What does immunotherapy involve?

Choose the false statement about T cytotoxic cells.

a. They stimulate B cells

b. They destroy virus-infected cells

c. They destroy cancer cells

d. They are activated by MHC I bound to antigens on APCs

e. They mediate the cellular branch of adaptive immunity

Match the T helper cell subset to its function. Some choices may not be used, and some may be used more than once.