19. Cancer Genetics

Which of the following is NOT a cause of cancer?

Which of the following statements about cancer is false?

Which of the following are enzymes are responsible for controlling the cell cycle?

How do we know that cancer cells contain defects in DNA repair?

How do we know that cancer development requires more than one mutation?

How do we know that malignant tumors arise from a single cell that contains mutations?

A tumor is a growing mass of abnormal cells. What must happen for a benign tumor to become malignant?

A tumor is a growing mass of abnormal cells. Give an example from this chapter of a benign tumor that becomes a malignant tumor.

A tumor is a growing mass of abnormal cells. Describe the difference between a benign tumor and a malignant tumor.

For the retinal cancer retinoblastoma, the inheritance of one mutated copy of RB1 from one of the parents is often referred to as a mutation that produces a 'dominant predisposition to cancer.' This means that the first mutation does not produce cancer but makes it very likely that cancer will develop. Define the 'two-hit hypothesis' for retinoblastoma.

Where are the major regulatory points in the cell cycle?