An example of a systems biology experiment might be __________.

• A. determining what gene mutation causes insulin resistance
• B. determining the normal biochemical function of the gene involved in insulin resistance
• C. comparing the insulin resistance gene in human, mouse, and chimpanzee genomes
• D. All of the listed responses are correct.
• E. determining how insulin resistance affects transcription of thousands of other genes in the genome

Answer: (E)

Verified step by step guidance

1. Understand the concept of systems biology: Systems biology is an approach in biology that focuses on complex interactions within biological systems, using a holistic perspective rather than a reductionist one.
2. Identify the key aspect of systems biology: It involves studying how different components of a biological system interact with each other, often using computational and mathematical modeling to understand these interactions.
3. Analyze the given options: Each option represents a different type of biological study. Systems biology would focus on interactions and effects on a larger scale, rather than isolated functions or comparisons.
4. Evaluate the options: Determining a gene mutation or its biochemical function is more reductionist, while comparing genes across species is comparative genomics. Systems biology would involve understanding broader interactions, such as how a condition affects the transcription of many genes.
5. Conclude with the correct systems biology approach: The option that involves determining how insulin resistance affects the transcription of thousands of other genes aligns with the systems biology approach, as it considers the broader impact on the genome.