Which of the following best describes the effect of progesterone on normal gallbladder function?

• A. Progesterone increases gallbladder contraction, promoting rapid bile release.
• B. Progesterone stimulates bile production in the liver.
• C. Progesterone decreases gallbladder motility, leading to slower bile release.
• D. Progesterone has no effect on gallbladder function.

Answer: (C)

Verified step by step guidance

1. Step 1: Begin by understanding the role of progesterone in the body. Progesterone is a hormone primarily involved in regulating the menstrual cycle and maintaining pregnancy. It also has effects on smooth muscle tissues, including those in the gastrointestinal system.
2. Step 2: Recall the function of the gallbladder. The gallbladder stores bile, which is released into the small intestine to aid in the digestion of fats. Gallbladder motility refers to its ability to contract and release bile.
3. Step 3: Consider how progesterone affects smooth muscle. Progesterone is known to relax smooth muscle tissue, which can decrease motility in organs like the gallbladder. Reduced motility means slower or less frequent contractions, leading to slower bile release.
4. Step 4: Evaluate the options provided in the question. The correct answer should align with the known physiological effect of progesterone on smooth muscle and gallbladder function.
5. Step 5: Conclude that the correct answer is: 'Progesterone decreases gallbladder motility, leading to slower bile release,' as this matches the biological effect of progesterone on smooth muscle relaxation.