During which stage of mitosis do the centromeres split?

• A. Anaphase
• B. Prophase
• C. Telophase
• D. Metaphase

Answer: (A)

Verified step by step guidance

1. Understand the stages of mitosis: Mitosis is divided into several stages: prophase, metaphase, anaphase, and telophase.
2. Identify the role of centromeres: Centromeres are the part of a chromosome that links sister chromatids. During mitosis, they play a crucial role in the separation of chromatids.
3. Recall the events of each mitotic stage: In prophase, chromosomes condense and become visible. In metaphase, chromosomes align at the cell's equatorial plate. In anaphase, centromeres split, allowing sister chromatids to separate and move to opposite poles. In telophase, the cell prepares to divide into two.
4. Focus on anaphase: During anaphase, the centromeres split, and the sister chromatids are pulled apart by the spindle fibers towards opposite poles of the cell.
5. Conclude with the correct stage: Based on the understanding of mitotic stages, the centromeres split during anaphase.