Which of the following is NOT a method used to control the glomerular filtration rate (GFR) in the kidneys?

• A. Tubuloglomerular feedback
• B. Neural regulation via sympathetic nervous system
• C. Myogenic mechanism
• D. Hormonal regulation by antidiuretic hormone (ADH)

Answer: (D)

Verified step by step guidance

1. Understand the concept of glomerular filtration rate (GFR), which refers to the rate at which the kidneys filter blood through the glomeruli. It is tightly regulated to maintain homeostasis.
2. Review the mechanisms that control GFR: Tubuloglomerular feedback, neural regulation via the sympathetic nervous system, and the myogenic mechanism. These are physiological processes directly involved in adjusting GFR.
3. Tubuloglomerular feedback involves the macula densa cells detecting changes in sodium chloride concentration in the filtrate and signaling adjustments to the afferent arteriole diameter to regulate GFR.
4. Neural regulation via the sympathetic nervous system can constrict afferent arterioles during stress or low blood pressure, reducing GFR to conserve fluid and maintain blood pressure.
5. Recognize that hormonal regulation by antidiuretic hormone (ADH) is not directly involved in controlling GFR. ADH primarily regulates water reabsorption in the collecting ducts, affecting urine concentration rather than filtration rate.