At what stage of mitosis do the replicated chromosomes (sister chromatids) separate?

• A. Anaphase
• B. Telophase
• C. Metaphase
• D. Prophase

Answer: (A)

Verified step by step guidance

1. Understand the process of mitosis, which is the division of a single cell into two genetically identical daughter cells. Mitosis consists of several stages: prophase, metaphase, anaphase, and telophase.
2. Recall that during prophase, the chromosomes condense and become visible, and the mitotic spindle begins to form.
3. In metaphase, the chromosomes align at the metaphase plate, which is the equatorial plane of the cell.
4. Recognize that anaphase is the stage where sister chromatids separate. The centromeres split, and the spindle fibers pull the chromatids apart toward opposite poles of the cell.
5. Finally, in telophase, the separated chromatids reach the poles, and the nuclear envelope re-forms around each set of chromosomes, completing the process of mitosis.